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This collection contains data from the National Cancer Insitute Clinical Trial
NCT00533949, "High-Dose or Standard-Dose Radiation Therapy and Chemotherapy With or Without Cetuximab in Treating Patients With Newly Diagnosed Stage III Non-Small Cell Lung Cancer That Cannot Be Removed by Surgery." It was sponsored by NCI's Radiation Therapy Oncology Group (RTOG) under under study number RTOG-0617. Clinical data which will allow users to compare the adverse events and treatments between arms in trial are located on the NCTN/NCORP Data Archive. Each patient's CT of the chest (including the adrenals) was obtained within 6 weeks of registration.Trial Description
Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as paclitaxel, carboplatin work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as cetuximab can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. It is not yet known whether high-dose radiation therapy is more effective than standard-dose radiation therapy when given together with combination chemotherapy with or without cetuximab in treating patients with non-small cell lung cancer. This randomized phase III trial is studying high-dose or standard-dose radiation therapy given together with chemotherapy with or without cetuximab to see how well they work in treating patients with newly diagnosed stage III non-small cell lung cancer that cannot be removed by surgery.For more information about the imaging protocol of this trial please see this document: https://www.rtog.org/LinkClick.aspx?fileticket=EmCYRSsCnRA%3d&tabid=40
Trial Outcomes
Results of the trial have been reported in the following publications:
Movsas B, Hu C, Sloan J, Bradley J, Komaki R, Masters G, Kavadi V, Narayan S, Michalski J, Johnson DW, Koprowski C, Curran WJ Jr, Garces YI, Gaur R, Wynn RB, Schallenkamp J, Gelblum DY, MacRae RM, Paulus R, Choy H. Quality of Life Analysis of a Radiation Dose-Escalation Study of Patients With Non-Small-Cell Lung Cancer: A Secondary Analysis of the Radiation Therapy Oncology Group 0617 Randomized Clinical Trial. JAMA Oncol. 2016 Mar;2(3):359-67. doi: 10.1001/jamaoncol.2015.3969. (linkPMC4786463)
Bradley JD, Paulus R, Komaki R, Masters G, Blumenschein G, Schild S, Bogart J, Hu C, Forster K, Magliocco A, Kavadi V, Garces YI, Narayan S, Iyengar P, Robinson C, Wynn RB, Koprowski C, Meng J, Beitler J, Gaur R, Curran W Jr, Choy H. Standard-dose versus high-dose conformal radiotherapy with concurrent and consolidation carboplatin plus paclitaxel with or without cetuximab for patients with stage IIIA or IIIB non-small-cell lung cancer (RTOG 0617): a randomised, two-by-two factorial phase 3 study. Lancet Oncol. 2015 Feb;16(2):187-99. doi: 10.1016/S1470-2045(14)71207-0. Epub 2015 Jan 16. (linkPMC4419359)
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title | Data Access |
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| Data AccessChoosing the Download option will provide you with a file to launch the TCIA Download Manager to download the entire collection. If you want to browse or filter the data to select only specific scans/studies please use the Search By Collection optionThis is a limited access data set. To request access please register an account on the NCTN Data Archive. After logging in, use the "Request Data" link in the left side menu. Follow the on screen instructions, and enter NCT00533949 when asked which trial you want to request. In step 2 of the Create Request form, be sure to select “Imaging Data Requested”. Please contact NCINCTNDataArchive@mail.nih.gov for any questions about access requests. Data Type | Download all or Query/Filter |
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url | https://wiki.cancerimagingarchive.net/download/attachments/33948334/NSCLC-Cetuximab-NBIA-manifest-1542748233353.tcia?version=1&modificationDate=1542748333870&api=v2 |
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url | https://nbia.cancerimagingarchive.net/nbia-search/?MinNumberOfStudiesCriteria=1&CollectionCriteria=NSCLC-Cetuximab |
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title | Detailed Description |
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Modalities | CT, RTSTRUCT, RTDOSE, RTPLANModalities | Number of PatientsParticipants | 490 | Number of Studies | 490 | Number of Series | 2116 | Number of Images | 75063 | Image Size (GB) |
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title | Citations & Data Usage Policy |
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| Citations & Data Usage Policy This collection is freely available to browse, download, and use for commercial, scientific and educational purposes as outlined in the Creative Commons Attribution 3.0 Unported License. See TCIA's Data Usage Policies and Restrictions for additional details. Questions may be directed to help@cancerimagingarchive.net. Please be sure to include the following citations in your work if you use this data set: Tcia limited license policy |
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| Clark K, Vendt B, Smith K, Freymann J, Kirby J, Koppel P, Moore S, Phillips S, Maffitt D, Pringle M, Tarbox L, Prior F. The Cancer Imaging Archive (TCIA): Maintaining and Operating a Public Information Repository, Journal of Digital Imaging, Volume 26, Number 6, December, 2013, pp 1045-1057. (paper) |
Other Publications Using This DataSee the TCIA Publications page for other work leveraging this collection. If you have a publication you'd like to add please contact the TCIA Helpdesk. | Localtab |
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| Version 1 (Current): Updated 201 / / Data Type | Download all or Query/Filter |
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Summary
This collection contains data from NCI Clinical Trial NCT00533949,
High-Dose or Standard-Dose Radiation Therapy and Chemotherapy With or Without Cetuximab in Treating Patients With Newly Diagnosed Stage III Non-Small Cell Lung Cancer That Cannot Be Removed by Surgery
.
Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as paclitaxel, carboplatin work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as cetuximab can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. It is not yet known whether high-dose radiation therapy is more effective than standard-dose radiation therapy when given together with combination chemotherapy with or without cetuximab in treating patients with non-small cell lung cancer.
This randomized phase III trial is studying high-dose or standard-dose radiation therapy given together with chemotherapy with or without cetuximab to see how well they work in treating patients with newly diagnosed stage III non-small cell lung cancer that cannot be removed by surgery.
Patient Population:
Newly diagnosed unresectable Stage III A or B non-small cell lung cancer (NSCLC); patients who present with N2 or N3 disease and an undetectable NSCLC primary tumor also are eligible; patients with supraclavicular or contralateral hilar adenopathy are ineligible.
- Search Clinical Trials for RTOG 0617: CT, Structures, RT Doses, RT Plans sent to ITC
For more information about the original aims of this trial please see this Protocol document: https://www.rtog.org/LinkClick.aspx?fileticket=EmCYRSsCnRA%3d&tabid=40
Additional Publication Resources:The Collection authors suggest the below will give context to this dataset: Movsas B, Hu C, Sloan J, Bradley J, Komaki R, Masters G, Kavadi V, Narayan S, Michalski J, Johnson DW, Koprowski C, Curran WJ Jr, Garces YI, Gaur R, Wynn RB, Schallenkamp J, Gelblum DY, MacRae RM, Paulus R, Choy H. Quality of Life Analysis of a Radiation Dose-Escalation Study of Patients With Non-Small-Cell Lung Cancer: A Secondary Analysis of the Radiation Therapy Oncology Group 0617 Randomized Clinical Trial. JAMA Oncol. 2016 Mar;2(3):359-67. doi: 10.1001/jamaoncol.2015.3969. (PMC4786463) Bradley JD, Paulus R, Komaki R, Masters G, Blumenschein G, Schild S, Bogart J, Hu C, Forster K, Magliocco A, Kavadi V, Garces YI, Narayan S, Iyengar P, Robinson C, Wynn RB, Koprowski C, Meng J, Beitler J, Gaur R, Curran W Jr, Choy H. Standard-dose versus high-dose conformal radiotherapy with concurrent and consolidation carboplatin plus paclitaxel with or without cetuximab for patients with stage IIIA or IIIB non-small-cell lung cancer (RTOG 0617): a randomised, two-by-two factorial phase 3 study. Lancet Oncol. 2015 Feb;16(2):187-99. doi: 10.1016/S1470-2045(14)71207-0. Epub 2015 Jan 16. (PMC4419359
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active | true |
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title | Data Access |
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| Data AccessChoosing the Download option will provide you with a file to launch the TCIA Download Manager to download the entire collection. If you want to browse or filter the data to select only specific scans/studies please use the Search By Collection option. Data Type | Download all or Query/Filter |
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Images ( XX.XGB) | Image Removed Image Removed
| Clinical Data on NCTN Data Archive | | Click the Versions tab for more info about data releases. Localtab |
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title | Detailed Description |
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| Detailed Description | |
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Modalities | Number of Patients | Number of Studies | Number of Series | Number of Images | Image Size (GB) | Please note Localtab |
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title | Citations & Data Usage Policy |
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| Citations & Data Usage Policy This collection is freely available to browse, download, and use for commercial, scientific and educational purposes as outlined in the Creative Commons Attribution 3.0 Unported License. See TCIA's Data Usage Policies and Restrictions for additional details. Questions may be directed to help@cancerimagingarchive.net. Please be sure to include the following citations in your work if you use this data set: Info |
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| | Clark K, Vendt B, Smith K, Freymann J, Kirby J, Koppel P, Moore S, Phillips S, Maffitt D, Pringle M, Tarbox L, Prior F. The Cancer Imaging Archive (TCIA): Maintaining and Operating a Public Information Repository, Journal of Digital Imaging, Volume 26, Number 6, December, 2013, pp 1045-1057. (paperOther Publications Using This DataSee the TCIA Publications page for other work leveraging this collection. If you have a publication you'd like to add please contact the TCIA Helpdesk.
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| Version 1 (Current): Updated 201 2019/ 04/ 15Data Type | Download all or Query/Filter |
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Images ( | XXXGB) Image Removed Image Removed
| DICOM Metadata Digest (CSV) | 7GB) |
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url | https://wiki.cancerimagingarchive.net/download/attachments/33948334/NSCLC-Cetuximab-NBIA-manifest-1542748233353.tcia?version=1&modificationDate=1542748333870&api=v2 |
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label | Search |
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url | https://nbia.cancerimagingarchive.net/nbia-search/?MinNumberOfStudiesCriteria=1&CollectionCriteria=NSCLC-Cetuximab |
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(Download requires the NBIA Data Retriever) |
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