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Figure 1 (top right of page): (A) Represents the tumor region containing 10000 voxels. (B) The corresponding tumor region with no CA leakage contamination (to be used for expected calculations). (C) Representative normal appearing white matter (WM) containing 2000 voxels. (D) Region representing the arterial input function (AIF). For a given parameter combination (TR=1.5s, TE=30ms, Flip angle= 60o, CA dosing = pre none bolus full, and B0= 3T), Figure 2 demonstrate example signal time course for all four ROI.

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Figure 2 (below): Example signal time course for a voxel within each of the four ROIs.

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