Background
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NCI announced new resources directed at for the Clinical Proteomic Tumor Analysis Consortium (CPTAC) (http://proteomics.cancer.gov/) . It is aimed at addressing NCI’s vision of integrating proteomic research with genomics so as to result in create a more unified understanding of tumor biology. As the CPTAC analyzable prospective available tissue resources begin began to ramp up, a few legacy TCGA genetic-focused cases -- CPTAC analyzed -- were noted to have diagnostic images that are presently accessible on The Cancer Imaging Archive (TCIA). |
The NCI Cancer Imaging Program is offering those few specific cases, access-linked here-in, "shared list" downloadable as an opportunity for researchers to explore and comprehend what such combined research resources might offer. They consist of 28 ovarian (TCGA-OV) and 14 breast (TCGA-BRCA) cases. Those imaging cases are easily downloadable as individual tumor specific groups from TCIA by entering separate queries of “shared lists” entitledon the drop-down Tool-menu “shared lists” under the separate titles of: CPTAC BreastAnalyzed (7 breast cases), and CPTAC OV Analyzed (12 ovarian cases). Those image cases can be down-loaded by entering the afore-mentioned “shared lists” on https://public.cancerimagingarchive.net/ncia/searchCustomList.jsf Their match-able CPTAC proteomic analysis data case matched CPTAC Proteomic Analysis Data is down-loadable from: https://cptac-data-portal.georgetown.edu/cptacPublic/ The case specific clinical data matching Clinical Data that matches each of those TCIA stored archive image cases are attached here as XLS sheets.
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An early CPTAC publication which reports on a more comprehensive collection of cases from those TCGA tumor data collections (BRCA and OV) can be found at: “Comprehensive quantitative analysis of ovarian and breast cancer tumor peptidomes”. Xu Z, et al., J Proteome Res. 2015 Jan 2;14(1):422-33. doi: 10.1021/pr500840w.
An excellent review of proteomic biomarkers is the publication: "Proteomics in cancer biomarkers discovery: challenges and applications." Sallam RM1. Dis Markers. 2015;2015:321370. doi: 10.1155/2015/321370.