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This collection combines advanced molecular imaging treatment response assessment through pre- and post-treatment FDG PET/CT scans with therapy of advanced head and neck cancer, including chemo-radiation therapy with and without addition of an EGFR inhibitor molecular targeted agent (Cetuximab). 

The Head-Neck Cetuximab collection consists of a subset of image data from RTOG 0522/ACRIN 4500, which was randomized phase III Trial of Radiation Therapy and Chemotherapy for stage III and IV Head and Neck carcinomas. The RTOG 0522/ACRIN 4500 protocols were activated in November 2005 and successfully completed accrual of 945 patients in 2009. As part of the RTOG 0522 trial, institutions had the option to join the RTOG 0522/ACRIN 4500 imaging study. The post-treatment FDG PET/CT scan was performed 8-9 weeks after completion of treatment before any nodal dissection.  For this reason the data was provided through two independent channels:

  • RTOG 0522: CT, Structures, RT Doses, RT Plans sent to ITC
  • ACRIN 4500: Quantitative PET (PET/CT) sent to ACRIN

For more information about the original aims of this trial please see this oral abstract: J Clin Oncol 29: 2011 (suppl; abstr 5500) here: .

Localtab Group

titleData Access

Data Access

Click the Download button to save a ".tcia" manifest file to your computer, which you must open with the NBIA Data Retriever. Click the Search button to open our Data Portal, where you can browse the data collection and/or download a subset of its contents.

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Images (48.8GB)


DICOM Metadata Digest (CSV)

Click the Versions tab for more info about data releases.

titleDetailed Description

Detailed Description

Collection Statistics




Number of Patients


Number of Studies


Number of Series


Number of Images


Image Size (GB)48.8

Supporting Documentation and metadata

Please note that 10 cases in this collection do not contain RT data.  Eight cases whose RT QA scores that were not "Per Protocol" or "Variation Acceptable" were excluded:  96, 133, 141, 143, 154, 182, 475, 478.  Also, subject 243 was ineligible and subject 260 expired prior to follow-up.

titleCitations & Data Usage Policy

Citations & Data Usage Policy 

This collection is freely available to browse, download, and use for commercial, scientific and educational purposes as outlined in the Creative Commons Attribution 3.0 Unported License. See TCIA's Data Usage Policies and Restrictions for additional details. Questions may be directed to

Please be sure to include the following citations in your work if you use this data set:

titleData Citation

Bosch, Walter R., Straube, William L., Matthews, John W., & Purdy, James A. (2015). Data From Head-Neck_Cetuximab. The Cancer Imaging Archive.

titleTCIA Citation

Clark K, Vendt B, Smith K, Freymann J, Kirby J, Koppel P, Moore S, Phillips S, Maffitt D, Pringle M, Tarbox L, Prior F. The Cancer Imaging Archive (TCIA): Maintaining and Operating a Public Information Repository, Journal of Digital Imaging, Volume 26, Number 6, December, 2013, pp 1045-1057. (paper)

Other Publications Using This Data

See the Head-Neck Cetuximab section on our Publications page for other work leveraging this collection. TCIA maintains a list of publications related to these datasets.

  1. AlZu'bi, Shadi et al. "Transferable Hmm Probability Matrices in Multi‐Orientation Geometric Medical Volumes Segmentation." Concurrency and Computation: Practice and Experience, 2019, p. e5214, doi:10.1002/cpe.5214.
  2. Edwards, Samuel et al. "Automated 3-D Tissue Segmentation Via Clustering." Journal of Biomedical Engineering and Medical Imaging, vol. 5, no. 2, 2018, p. 08, doi: 10.14738/jbemi.52.4204.
  3. Gruselius, H. (2018). Generative models and feature extraction on patient images and structure data in radiation therapy. Retrieved from

  4. Ryalat MH, Laycock S, Fisher M, editors. Automatic Removal of Mechanical Fixations from CT Imagery with Particle Swarm Optimisation. International Conference on Bioinformatics and Biomedical Engineering; 2017: Springer. DOI: 10.1007/978-3-319-56148-6_37
  5. Sando, Yusuke et al. "Real-Time Interactive Holographic 3d Display with a 360 Degrees Horizontal Viewing Zone." Appl Opt, vol. 58, no. 34, 2019, pp. G1-G5, doi:10.1364/AO.58.0000G1.
  6. Scarpelli, M. et al. "Optimal Transformations Leading to Normal Distributions of Positron Emission Tomography Standardized Uptake Values." Phys Med Biol, vol. 63, no. 3, 2018, p. 035021, doi:10.1088/1361-6560/aaa175
  7. Sinha, A. et al. "The Deformable Most-Likely-Point Paradigm." Med Image Anal, vol. 55, 2019, pp. 148-164, doi:10.1016/
  8. Sinha, A. et al. "Recovering Physiological Changes in Nasal Anatomy with Confidence Estimates." First International Workshop on Uncertainty for Safe Utilization of Machine Learning in Medical Imaging, UNSURE 2019, edited by Hayit Greenspan et al., Springer, 2019. doi:10.1007/978-3-030-32689-0_12.
  9. Tang, Hao et al. "Clinically Applicable Deep Learning Framework for Organs at Risk Delineation in Ct Images." Nature Machine Intelligence, vol. 1, no. 10, 2019, pp. 480-491, doi:10.1038/s42256-019-0099-z.
  10. Teske, Hendrik et al. "Handling Images of Patient Postures in Arms up and Arms Down Position Using a Biomechanical Skeleton Model." Current Directions in Biomedical Engineering, vol. 3, no. 2, 2017, pp. 469-472, doi:10.1515/cdbme-2017-0099.
  11. Wong, Jordan et al. "Comparing Deep Learning-Based Auto-Segmentation of Organs at Risk and Clinical Target Volumes to Expert Inter-Observer Variability in Radiotherapy Planning." Radiother Oncol, vol. 144, 2019, pp. 152-158, doi:10.1016/j.radonc.2019.10.019.
  12. Zhu, Wentao. "Deep Learning for Automated Medical Image Analysis." Computer Science, vol. Ph.D, University of California, Irvine, 15 March 2019 2019. general editor, Xiaohui Xie et al.,
  13. Zhu, Wentao et al. "Anatomynet: Deep Learning for Fast and Fully Automated Whole‐Volume Segmentation of Head and Neck Anatomy." Medical Physics, vol. 46, no. 2, 2018, pp. 576-589, doi:

If you have a publication you'd like to add please contact the TCIA Helpdesk.


Version 1 (Current): Updated 2013/11/14

Data TypeDownload all or Query/Filter
Images (48.8GB)


(Requires the NBIA Data Retriever.)

DICOM Metadata Digest (CSV)