Summary
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The |
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Cancer Genome Atlas (TCGA) Ovarian Phenotype Research Group is part of the |
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Cancer Imaging Project TCGA Radiology Initiative; an effort to build a research community focused on |
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According to the TCGA page on Ovarian serous cystadenocarcinoma, TCGA researchers have:
- Confirmed that mutations in gene TP53 are present in more than 96 percent of ovarian cases. The TP53 gene encodes a tumor suppressor protein that normally prevents cancer development.
- Analyzed gene expression patterns and found signatures that correlate with poor or better survival. Patients whose tumors showed a gene expression pattern associated with poor survival lived a period 23 percent shorter than patients without that signature.
- Affirmed the existence of four distinct subtypes of ovarian cancer through examination of RNA transcription and DNA methylation patterns.
- Substantiated observations that patients with mutations in their BRCA1 and BRCA2 genes have better odds of survival than patients without mutations in those genes. Approximately 21 percent of tumor cases in this study exhibited BRCA1 and BRCA2 mutations.
- Identified therapeutic opportunities by searching for existing drugs that might correct a genomic error that causes a patient's ovarian cancer. The search yielded 68 genes that could be targeted by existing Food and Drug Administration-approved or experimental therapeutic compounds.
Research and Publications
Per TCGA and TCIA Guidelines formal permission requests are still required to submit publications using TCGA-OV data. Please see the following links for more information about the freedom-to-publish criteria for these data sets:
Data Source | Status |
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No restrictions; all data available without limitations | |
Projects have not reached 100 imaging cases; Please check with cancerimagingarchive@mail.nih.gov prior to any publication |
Please contact us at cancerimagingarchive@mail.nih.gov if you have any questions about these policies, or would like to join our public mailing list and be kept in the loop about new data releases and other related news as this effort moves forward.
TCGA-OV Marker Paper and Image Source Sites (ISS)
connecting cancer phenotypes to genotypes by providing clinical images matched to tissue specimens analyzed for The Cancer Genome Atlas (TCGA). |
Imaging Source Site (ISS) Groups will be populated are being formed and governed by participants from institutions that have provided imaging data to the archive for a given cancer type. Modeled after TCGA analysis groups, these ISS groups are given the opportunity to publish a marker paper for a given cancer type per the aforementioned publication policy. It is hoped that this type per the guidelines in the table above. This opportunity will generate increased participation in the building of these multi-institutional data sets that as they become an open community resource. Current Current The Cancer Genome Atlas Ovarian Cancer Collection (TCGA-OV source ) source sites include:
- Washington University St. Louis
- MSKCC
- UPMC
- MDACC
- UNC
Please contact Dr. Evis Sala (salae@mskccsalae@mskcc.org) if you have scientific questions you would like to direct to the for TCGA-OV ISS, or are interested in collaborating with their group.
References
The following links contain publications from the main TCGA project, as well as their posted publication guidelines.
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Publications
TCGA Ovarian Phenotype Research Group Publications
- Vargas HA, Huang EP, Lakhman Y, Ippolito JE, Bhosale P, Mellnick V, Shinagare AB, Anello M, Kirby J, Fevrier-Sullivan B, Freymann J, Jaffe CC, Sala E. Radiogenomics of High-Grade Serous Ovarian Cancer: Multireader Multi-Institutional Study from the Cancer Genome Atlas Ovarian Cancer Imaging Research Group. Radiology. 2017 Jun 22:161870. doi: 10.1148/radiol.2017161870. (link)
Publications written by other members of the research community can be found on our TCIA Publications page. Please contact us at help@cancerimagingarchive.net if you have a publication you would like us to add.
TCGA Genomics Publications
Read about the TCGA-OV genomic study. Additional TCGA publications can be found at: http://cancergenome.nih.gov/publications.
Publication Policies
Per TCGA and TCIA Guidelines, formal permission requests are no longer required to submit publications using TCGA-OV data. Please see the following links for more information about the freedom-to-publish criteria for these data sets:
Data Source | Status |
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No restrictions; all data available without limitations. | |
No restrictions; all data available without limitations. |
Please contact us at help@cancerimagingarchive.net if you have any questions about these policies.