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1. Single-breast ipsilateral cropped DCE images
   1. As this was done primarily for computational efficiency, low matrix-sized images (<384 voxels per row) were stored and processed without cropping
2. Enhancement maps
   1. PE_early: Enhancement at effective post-contrast time 120-150 sec
   2. PE_late: Enhancement at effective post-contrast time ~450 sec
   3. SER: Signal enhancement ratio    SER =  PE_early / PE_late
      Note: SER values were scaled by 1000 for integer storage. DICOM software utilizing the rescale slope and intercept fields [ DICOM fields (0028, 1052-1054)] should return the original SER values in the range from 0.0 – 3.0.
   4. All maps were stored as DICOM MRI objects
3. Functional Tumor Volume (FTV) analysis mask
   1. Segmentation storing FTV masking. Encodes:
      1. Pre-contrast background threshold
      2. Minimum PE threshold (70% nom.)
      3. Manually defined rectangular volume of interest (VOI) for enhancing tumor analysis
      4. Manually defined “OMIT” regions used to exclude non-tumor enhancing regions that encroached on the rectangular VOI
   2. Stored as DICOM SEG object
   3. See this document for further information: Analysis mask files description

These DCE derived series can be identified either by Series Description (0008,103e) or by Series Number (0020,0011). See Table 1 for series identification details.

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Figure 2 shows the enrollment numbers and exclusions used to determine the analysis cohort for the primary analysis. For this TCIA collection we include MRI studies from 385 of the 388 eligible subjects, three being excluded due to having no analyzable MRI studies received by the central imaging lab. The 116 patients excluded from the primary analysis as “Not Randomized” were those screened out of I‑SPY 2, most commonly due to being in the low-risk category (HR+/HER2- subtype with low MammaPrint score). Note that all these patients have baseline MRI studies included in this collection, and some were included in the ACRIN-6698 test/retest repeatability arm. A separate TCIA download option is provided for researchers who wish to focus on the 242-patient cohort used in the primary analysis. These subjects all had MRI studies with DWI scans that passed the QC evaluations at baseline and at least one later time point. One other download option is provided for the 71-patient cohort with analyzable test/retest. (Do you want a link here for the 20210405,192312.TestreTest.1573ser.TCIAmfst) The primary aim and test/retest studies are the only ones guaranteed to have tumor segmentations and DWI derived objects in this collection.

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