This collection is comprised of 390 patients who presented with vestibular schwannoma (VS, n=73), trigeminal neuralgia (TGN, n=119) or metastatic disease (M, n=198) and were subsequently treated with Gamma Knife (Eleka AB, Stockholm, Sweden) stereotactic radiosurgery. For each patient, the treatment indication is designated with a suffix on their patient ID (VS, TGN or M).

All patients are provided with at least one high-resolution (1 mm slice thickness) T1 FLASH trans-axial MR imaging study and their corresponding high-resolution axial planning CT. When available, treatment planning data (struct, dose, plan), alternative MR sequences (FLAIR, T2 CISS, etc.) and follow-up MR imaging studies were collected. Each MR image used during treatment planning was registered to the CT frame of reference and is provided with the DICOM registration file and the aligned secondary image. Additionally, for each patient in the cohort, hippocampal contours generated by multiple institutional observers are provided in a separate structure set. In total, this dataset contains: CT (n=390), MR (n=3868), REG (n=872), DOSE (n=928), PLAN (n=928), planning STRUCT (n=931), and hippocampal research STRUCT (n=390).

Planning Data:

Gamma Knife planning studies are designated by “Gamma Knife Planning Data” in the study description DICOM header tag. For each patient, MIM (MIM Software, Beachwood, OH) was used to generate a rigid registration between CT and each MR sequence and the registration accuracy was validated using the stereotactic frame fiducial markers. From each registration, a DICOM RTREG file and aligned secondary are provided, with each aligned secondaries series indicated by “[original series description] Co-registered to CT” in the series description DICOM header tag. During export from GammaPlan (Eleka AB, Stockholm, Sweden), the treatment planning files was provided in duplicate for each imaging modality frame of reference (CT and each MR sequence).

Follow-up Data:

When available, patient follow-up images were collected between the provided treatment date and either the next Gamma Knife treatment or up-to approximately two years following treatment. In total, 197 patients are provided with follow-up imaging studies, with a median of 2 (range 1-13) follow-up studies provided per patient. Each follow-up imaging study is designated as “Follow-up Image Set #”. Each follow-up date exists in a unique frame of reference and was not co-registered to the original treatment planning CT volume.

Hippocampal Contours:

Three independent observers generated hippocampal contours from the CT aligned-secondary of the T1-weighted MR image, with the resultant contours saved to the CT frame of reference. In total, 744 unique left, right contour pairs were generated (observer 1, n=390; observer 2, n=247; observer 3, n=107). In addition to hippocampal contours, the region grow tool was used to generate a head contour (ROI name ‘head’) to mask out the stereotactic frame and remove most of the reconstruction artifacts on the inferior extent of the image volume.

Additional Information

All MR images designated as ‘Co-registered to CT’ in the Series Description were interpolated to the CT frame of reference, potentially altering the field of view or voxel resolution. For all co-registered MR images, the original primary images and registration files are provided for use as needed.