Summary
The MRI data consist of diffusion-weighted images (DWIs), dynamic contrast-enhanced (DCE) images, and multi-flip data for T1-mapping. The MRIs were obtained using a dedicated 16-channel bilateral breast coil at 3.0T (Philips Achieva with the MammoTrak table). DWIs were acquired with a single-shot spin echo (SE) echo planar imaging (EPI) sequence in three orthogonal diffusion encoding directions (x, y, and z). For 14 patients, b = 0 and 500 s/mm2, TR/TE = 2500 ms/45 ms Δ = 21.4 ms, δ = 10.3 ms and 10 signal acquisitions were acquired. For 19 patients, b = 0 and 600 s/mm2, TR/TE = “shortest” (range = 1800 - 3083 ms/43 - 60 ms) Δ = 20.7 - 29 ms, δ = 11.4 - 21 ms and 10 signal acquisitions were acquired. For four patients, b = 50 and 600 s/mm2 for two patients), TR/TE = “shortest” (range = 1840 - 3593 ms/43 - 60 ms) Δ = 20.6 - 29 ms, δ = 11.5 - 21 ms and 10 signal acquisitions were acquired. Prior to the DCE-MRI acquisition, data for constructing a T1 map were acquired with an RF-spoiled 3D gradient echo multi-flip angle approach with ten flip angles from 2 to 20 degrees in 2o increments. For both the T1 map and DCE scans, TR = 7.9 ms, TE = 4.6 ms, and the acquisition matrix was 192x192x20 (full-breast) over a sagittal square field of view (22 cm2) with slice thickness of 5 mm. For the DCE study, each 20-slice set was collected in 16 seconds at 25 time points for just under seven minutes of dynamic scanning. A catheter placed within an antecubital vein delivered 0.1 mmol/kg (9 – 15 mL, depending on patient weight) of gadopentetate dimeglumine, Gd-DTPA, (Magnevist, Wayne, NJ) at 2 mL/sec (followed by a saline flush) via a power injector (Medrad, Warrendale, PA) after the acquisition of the first three dynamic scans (baseline).
QIN-Breast-02 Multi-center Study
An extension of this QIN-BREAST collection is available via the QIN-BREAST-02 collection. It contains updated scan protocols and data collected at both Vanderbilt University Medical Center and the University of Chicago to demonstrate similar results at multiple sites (both using Philips 3T MR scanners).
About the NCI QIN
The mission of the QIN is to improve the role of quantitative imaging for clinical decision making in oncology by developing and validating data acquisition, analysis methods, and tools to tailor treatment for individual patients and predict or monitor the response to drug or radiation therapy. More information is available on the Quantitative Imaging Network Collections page. Interested investigators can apply to the QIN at: Quantitative Imaging for Evaluation of Responses to Cancer Therapies (U01) PAR-11-150.
Data Access
Data Type | Download all or Query/Filter | License |
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Images (DICOM, 11.286 GB) | (Download requires the NBIA Data Retriever) | |
QIN-Breast Treatment Response (XLS, 16 kB) |
Click the Versions tab for more info about data releases.
Additional Resources for this Dataset
The NCI Cancer Research Data Commons (CRDC) provides access to additional data and a cloud-based data science infrastructure that connects data sets with analytics tools to allow users to share, integrate, analyze, and visualize cancer research data.
- Imaging Data Commons (IDC) (Imaging Data)
Detailed Description
Radiology Image Statistics | |
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Modalities | MR, PT, CT |
Number of Patients | 68 |
Number of Studies | 216 |
Number of Series | 536 |
Number of Images | 102,451 |
Image Size (GB) | 11.4 |
Metadata
Treatment Response information: QIN-Breast_TreatmentResponse(2014-12-16).xlsx
Citations & Data Usage Policy
Users must abide by the TCIA Data Usage Policy and Restrictions. Attribution should include references to the following citations:
Data Citation
Li, X., Abramson, R. G., Arlinghaus, L. R., Chakravarthy, A. B., Abramson, V. G., Sanders, M., & Yankeelov, T. E. (2016). Data From QIN-Breast (Version 2) [Data set]. The Cancer Imaging Archive. https://doi.org/10.7937/K9/TCIA.2016.21JUEBH0
Funding Acknowledgement
Please be sure to acknowledge the award that supported collection and sharing of this dataset (U01 CA142565, PI Thomas E. Yankeelov).
Publication citation:
Li X, Abramson RG, Arlinghaus LR, Kang H, Chakravarthy AB, Abramson VG, Farley J, Mayer IA, Kelley MC, Meszoely IM, Means-Powell J, Grau AM, Sanders M, Yankeelov TE. Multiparametric magnetic resonance imaging for predicting pathological response after the first cycle of neoadjuvant chemotherapy in breast cancer. Investigative Radiology, 2015 Apr;50(4):195-204. PMCID: PMC4471951
TCIA Citation
Clark K, Vendt B, Smith K, Freymann J, Kirby J, Koppel P, Moore S, Phillips S, Maffitt D, Pringle M, Tarbox L, Prior F. The Cancer Imaging Archive (TCIA): Maintaining and Operating a Public Information Repository, Journal of Digital Imaging, Volume 26, Number 6, December, 2013, pp 1045-1057. DOI: 10.1007/s10278-013-9622-7
Other Publications Using This Data
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Version 2 (Current): Updated 2020/01/10
Lifted "Restricted access" embargo. No changes to files were required.
Version 1: Updated 2015/09/04
Data Type | Download all or Query/Filter |
---|---|
Images (DICOM, 11.286GB) | (Download requires the NBIA Data Retriever.) |
QIN-Breast Treatment Response (XLS) |