Detailed DescriptionImage Statistics |
|
---|
Modalities |
| Number of Patients |
| Number of Studies |
| Number of Series |
| Number of Images |
| Images Size (GB) |
|
Nina Mayr's Additional Information: Purpose: The understanding of biological processes occurring within the tumor environment during the ongoing radiation therapy course remains a major knowledge gap in radiation oncology for cervical cancer and other malignancies. The CCTH collection seeks to help fill this gap by providing functional/molecular tumor imaging data sets – spatially to assess tumor heterogeneity and temporally across the radiation therapy course in advanced cervical cancer patients. CCTH Collection: The CCTH collection shares functional/molecular imaging data sets (performed on an NCI funded R01 award1) that were prospectively acquired in clinical patients with advanced stage IB2 – IVA cervical cancer, who were treated with standard combined radiation therapy with concurrent Cisplatin-based chemotherapy. Both functional MRI, consisting of T1- and T2-weighted, dynamic contrast enhanced (DCE), diffusion-weighted (DWI) and post-contrast MRI, and 18FDG PET/CT were obtained in parallel and prospectively timed with the radiation therapy course. Imaging was performed, according to a standardized multi-institutional protocol, at three time points/radiation dose levels: before treatment start (dose 0), early during the treatment course (2-2.5 weeks after treatment start/dose 20-25 Gy) and at mid-treatment (4-5 weeks after treatment start/dose 45-50 Gy). Contours (regions of interest) of the tumor volumes, as defined by the gold standard of T2-weighetd MRI and coregistration with PET/CT, are included in the CCTH for each case and each imaging time point. The resulting prospective multi-variable imaging data sets, obtained from the various imaging modalities at different treatment time points, allow detailed study of the evolution of functional/molecular tumor properties before and during radiation/chemotherapy course. These include voxel-wise heterogeneity assessment of the structural properties (tumor volume on T2-weighted MRI) and, in parallel, the functional characteristics on DCE, DWI MRI and 18FDG PET. These intra-treatment functional phenomena from various functional imaging modalities may have the potential for clinical translation into important actionable early imaging prognosticators and predictors for long-term treatment outcome. For example, vascular tumor properties (as reflected by DCE MRI) are highly significant for tumor oxygenation, which in turn profoundly influences radiation response. For example, our early investigations suggest that dynamic contrast enhancement (indicative of tumor microvasculature) improves early in the treatment course and heterogeneity decreases, particularly in responders [refs], while FDG heterogeneity tends to show reduced metabolic activity, which commonly becomes evident later in the radiation treatment course refs [ref/Bowen]. Our pilot data from a prior NCI/NIH award that laid the foundation for this work [ref], have also suggested that functional tumor properties early during treatment (2-4 weeks into treatment) have significant predictive value for ultimate tumor control and survival in cervical cancer [refs]. If unfavorable tumor properties, which correlate with poor treatment outcome, can be identified in patients early during treatment, the therapy regimen may be individually adapted accordingly to improve the outcome. Translation to clinical practice: The complex data sets, from multi-modality and multi-parametric imaging studies at various treatment time points, were designed to be shared with the scientific community with interest and related specialties to advance the functional imaging-based tumor heterogeneity assessment in cervical cancer patients. The current data set allows further extraction of radiomics data to optimize potential and efficacy of functional imaging in improving the management of the patients with advanced cervical cancer. The ultimate goal is to facilitate the clinical translation that is readily available to community settings in the U.S. and abroad. Therefore, the imaging sequences used in this research are widely available and applicable in community settings. This is important because advanced cervical cancer is largely treated in the community settings and is highly prevalent cancer worldwide, particularly among woman in underserved and economically disadvantaged communities. Future outlook: We thank the National Cancer Institute and National Institute of Health for their support of this imaging research; and the members of CIP and TCIA for their deep expertise and their help in establishing the CCTH collection. While our initial studies have established important principles on the use of functional and molecular imaging in cervical cancer, it has been our intent and hope when donating this data, that the data sets of this collection may serve a resource to investigators into the future as image analysis and radiomics techniques will continue to advance, well beyond the time course of our own studies. Because cervical cancer remains a common cancer in the women, particularly in low- and middle-income countries worldwide, future studies will need to address the feasibility and accessibility of imaging to these patients, such as affordable cost, availability of imaging modalities involved, technical processing requirements (radiomic feature extraction, data reduction and statistical analysis/learning models) and education. |