Page History

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The National Cancer Institute (NCI) has exercised a series of contracts with specific academic sites for collection of repeat "coffee break," longitudinal phantom, and patient data for a range of imaging modalities (currently computed tomography [CT positron ] positron emission tomography ([PET) CT] CT, dynamic contrast-enhanced magnetic resonance imaging [DCE MRI]), diffusion-weighted [DW] MRI) and organ sites (currently lung, breast, and neuro). The goals are as follows:

1. Develop a consensus on requirements for quantity assurance methods for on longitudinal studies using phantom data as applied to each modality above,.
2. Develop a consensus on the stability of imaging platforms using repeat and longitudinal phantom measurements over the time period that therapy would be exercised,.
3. Develop a consensus on methods to measure the minimum change that can be measured using repeat and longitudinal patient or volunteer studies.
4. Provide access to results of measurements performed on these databases by each academic site to encourage a comparison on methodologies,.
5. Provide consensus-based juried publications to encourage a broad acceptance of the methods described above.
6. Provide a resource for NCI research networks that address quantitative imaging such as the Quantitative Imaging Network (QIN):   http://grants.nih.gov/grants/guide/pa-files/PAR-11.150.html.

The databases are being provided with a timely goal of 18 months within an 18-month time frame , namely from the time the contract was initiated, and the results are published results within less than 2 years. The methods for data collection, analysis, and analysis including results are described in the new Combined RIDER white White Paper Report (Sept 2008):

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The RIDER project will be replaced when the QIN initiative is fully implemented as this . This research network will be tasked to create database resources collected from phase 1-3 clinical trials, where clinical outcomes will be included in the meta datametadata: http://grants.nih.gov/grants/guide/pa-files/PAR-11-150.html.

ACADEMIC SITE COLLECTIONS: Focus on

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Methods for

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Data Analysis

RIDER Lung CT: MSKCC

• Repeat CT Measurements: Human subjects: Lung.
• Download the related lesion notes: MSKCC RepeatCT Lesion notes for RIDER.xls.
• Download the related publication: Zhaob-RepeatCT Radiology2009.pdf.
• 2012-10-18 Update: It was brought to our attention that the RIDER-8509201188 patient contained 2 identical image series rather than the correct secondary/repeat series. The duplicate series has been removed (UID: 1.3.6.1.4.1.9328.50.1.64033480205396366773922006817138551096), but we are unable to obtain the correct series at this point.
  
  
  

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• Repeat measurements: PET/CT phantoms.
• Consists of repeat measurement PET/CT phantom scan collections carried out under the aegis of the Society of Nuclear Medicine (SNM) to discern the uniformity of clinical imaging instrumentation at various sites. They were obtained in cooperation with Society of Nuclear Medicine SNM as a resource for increased quantitative understanding of machine acquisition, analytic reproducibility and image processing.
• Additional annotation data about this collection can be viewed in the following document: Ge68Phantom.doc.

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• Longitudinal PET/CT human studies: Lung.
• 2012-02-22 Update: It was brought to our attention that RIDER-1817358092 and RIDER-2617411955 appeared to be the same patient.  We have gone back to University of Washington and confirmed this is to be true.  For now, we will leave both patients in place but plan to eventually delete RIDER-1817358092.  RIDER-2617411955 contains some additional series not found in the other patient ID and is what we would advise users to utilize in their research.
  
  

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• Repeat human subject studies: Neuro,
• Dynamic Contract Enhanced studies: DCE MRI:.
• Diffusion weighted imaging: DWI MR.
• Diffusion tensor imaging: diffusion tensor (DT) MRI.

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• Repeat measurements: Human subjects: Breast.
• DCE MRI.
• ISMRM 2009 poster demonstrates how each of the "coffee break" exams were used as an estimate of each patient's null hypothesis, i.e. distribution associated with no change, and thus supports the estimate of the null's nulls 97.5 percentile for subsequent estimation of early response to neoadjuvant chemotherapy on an individual patient basis.
  
  

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• Repeat measurement: Phantom studies.
• DCE MRI.
• RIDER_MR_Phantom_Data_Summary.pdf provides a summary of the images in this collection.
• RIDER_PhantomMR_Key.pdf provides a key for understanding their presentation in NBIA.

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MULTI SITE STUDY (Total of 20 sites): Organized under a contract with the University of Michigan ( Under development: 2009)

• Repeat measurements.
• Diffusion Weighted Imaging (DWI)
• Phantom measurements.
• Human subjects.
• White Paper: http://www.neoplasia.com/pdf/manuscript/v11i02/neo081328.pdf.

SOCIETY DATA COLLECTIONS

RSNA QIBA AND NCI (RIDER and IRAT) (2009-beyond: under development)

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FDA CDRH: Partly funded by NCI and NIBIB

• Phantom FDA

NIST

• NIST The National Institute of Standard and Technology has NCI NBIA National Biological Imaging Archive data and data from other data sources.
• See Biochange 2008.
• http://www.itl.nist.gov/iad/894.05/biochange2008/Biochange2008-webpage.htm

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This data collection was originally supported under supplemental funding for the Lung Image Database Consortium (LIDC) U01 project and focused on the collection of longitudinal studies using X-ray CT for monitoring the response to therapy. The data came primarily from MDACC the M.D. Anderson Cancer Center and several of the LIDC academic sites. The data is not annotated and is not hosted in TCIA The Cancer Imaging Archive but can be downloaded from the National Biomedical Imaging Archive (NBIA).