Summary
The Reference Image Database to Evaluate Therapy Response (RIDER) is a targeted data collection used to generate an initial consensus on how to harmonize data collection and analysis for quantitative imaging methods applied to measure the response to drug or radiation therapy. The long term goal is to provide a resource to permit harmonized methods for data collection and analysis across different commercial imaging platforms to support multi-site clinical trials, using imaging as a biomarker for therapy response. Thus, the database should permit an objective comparison of methods for data collection and analysis as a national and international resource as described in the first RIDER white paper report (2006).All the image data are DICOM compliant. The data collection has two phases as described below, which have resulted in several distinct image Collections.
RIDER Contracts (2007-Beyond)
The National Cancer Institute (NCI) has exercised a series of contracts with specific academic sites for collection of repeat "coffee break," longitudinal phantom, and patient data for a range of imaging modalities (currently computed tomography [CT] positron emission tomography [PET] CT, dynamic contrast-enhanced magnetic resonance imaging [DCE MRI], diffusion-weighted [DW] MRI) and organ sites (currently lung, breast, and neuro). The goals are as follows:
- Develop a consensus on requirements for quantity assurance methods on longitudinal studies using phantom data as applied to each modality above.
- Develop a consensus on the stability of imaging platforms using repeat and longitudinal phantom measurements over the time period that therapy would be exercised.
- Develop a consensus on methods to measure the minimum change that can be measured using repeat and longitudinal patient or volunteer studies.
- Provide access to results of measurements performed on these databases by each academic site to encourage a comparison on methodologies.
- Provide consensus-based juried publications to encourage a broad acceptance of the methods described above.
- Provide a resource for NCI research networks that address quantitative imaging such as the Quantitative Imaging Network (QIN): http://grants.nih.gov/grants/guide/pa-files/PAR-11.150.html.
The databases are being provided within an 18-month time frame from the time the contract was initiated, and the results are published within less than 2 years. The methods for data collection, analysis, and results are described in the new Combined RIDER White Paper Report (Sept 2008):
The RIDER project will be replaced when the QIN initiative is fully implemented. This research network will create database resources collected from phase 1-3 clinical trials, where clinical outcomes will be included in the metadata: http://grants.nih.gov/grants/guide/pa-files/PAR-11-150.html.
ACADEMIC SITE COLLECTIONS: Focus on Methods for Data Analysis
RIDER Lung CT: MSKCC
- Repeat CT Measurements: Human subjects: Lung.
- Download the related lesion notes: MSKCC RepeatCT Lesion notes for RIDER.xls.
- Download the related publication: Evaluating Variability in Tumor Measurements from Same-day Repeat CT Scans of Patients with Non–Small Cell Lung Cancer, 2009.
- 2012-10-18 Update: It was brought to our attention that the RIDER-8509201188 patient contained 2 identical image series rather than the correct secondary/repeat series. The duplicate series has been removed (UID: 1.3.6.1.4.1.9328.50.1.64033480205396366773922006817138551096), but we are unable to obtain the correct series at this point.
Lung CT Statistics | Updated 11/14/2013 |
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Modalities | CT |
Number of Participants | 32 |
Number of Studies | 46 |
Number of Series | 63 |
Number of Images | 15,419 |
Images Size (GB) | 7.55 |
RIDER Phantom PET-CT: UNIVERSITY OF WASHINGTON
- Repeat measurements: PET/CT phantoms.
- Consists of repeat measurement PET/CT phantom scan collections carried out under the aegis of the Society of Nuclear Medicine (SNM) to discern the uniformity of clinical imaging instrumentation at various sites. They were obtained in cooperation with SNM as a resource for increased quantitative understanding of machine acquisition, analytic reproducibility and image processing.
- 2015-01-26 Update: Additional annotation data about this collection can be viewed in the following document: Ge68Phantom_2015.doc.
Phantom PET-CT Collection Statistics | |
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Modalities | CT, PT |
Number of Participants | 20 |
Number of Studies | 20 |
Number of Series | 60 |
Number of Images | 2,231 |
Images Size (MB) | 689 |
RIDER Lung PET-CT: UNIVERSITY OF WASHINGTON
- Longitudinal PET/CT human studies: Lung.
- 2012-02-22 Update: It was brought to our attention that RIDER-1817358092 and RIDER-2617411955 appeared to be the same patient. We have gone back to University of Washington and confirmed this is to be true. For now, we will leave both ID in place but plan to eventually delete RIDER-1817358092. RIDER-2617411955 contains some additional series not found in the other patient ID and is what we would advise users to utilize in their research.
Lung PET CT Statistics | Updated 11/14/2013 |
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Modalities | CT, PT |
Number of Participants | 244 |
Number of Studies | 275 |
Number of Series | 1349 |
Number of Images | 269,511 |
Images Size (GB) | 78.7 |
RIDER NEURO MRI: DUKE UNIVERSITY
- Repeat human subject studies: Neuro,
- Dynamic Contract Enhanced studies: DCE MRI.
- Diffusion weighted imaging: DWI MR.
- Diffusion tensor imaging: diffusion tensor (DT) MRI.
Neuro MRI Statistics | |
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Modalities | MR |
Number of Participants | 19 |
Number of Studies | 108 |
Number of Series | 368 |
Number of Images | 70,220 |
Images Size (GB) | 7.3 |
RIDER Breast MRI: UNIVERSITY OF MICHIGAN
- Repeat measurements: Human subjects: Breast.
- DCE MRI.
- ISMRM 2009 poster demonstrates how each of the "coffee break" exams were used as an estimate of each patient's null hypothesis, i.e. distribution associated with no change, and thus supports the estimate of the nulls 97.5 percentile for subsequent estimation of early response to neoadjuvant chemotherapy on an individual patient basis.
Breast MRI Statistics | Updated 2011/11/08 |
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Modalities | MR |
Number of Participants | 5 |
Number of Studies | 10 |
Number of Series | 40 |
Number of Images | 1500 |
RIDER PHANTOM MRI: MDACC
- Repeat measurement: Phantom studies.
- DCE MRI.
- RIDER_MR_Phantom_Data_Summary.pdf provides a summary of the images in this collection.
- RIDER_PhantomMR_Key.pdf provides a key for understanding their presentation in NBIA.
Phantom MRI Statistics | |
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Modalities | MR |
Number of Participants | 10 |
Number of Studies | 13 |
Number of Series | 45 |
Number of Images | 7,061 |
Images Size (GB) | 3.4 |
ACADEMIC SITE COLLECTIONS: Focus on harmonized methods for data collection
MULTI SITE STUDY (Total of 20 sites): Organized under a contract with the University of Michigan
- Repeat measurements.
- DWI
- Phantom measurements.
- Human subjects.
- White Paper: Padhani, A. R., Liu, G., Mu-Koh, D., Chenevert, T. L., Thoeny, H. C., Takahara, T., Dzik-Jurasz, A., Ross, B. D., Van Cauteren, M., Collins, D., Hammoud, D. A., Rustin, G. J. S., Taouli, B., & Choyke, P. L. (2009). Diffusion-Weighted Magnetic Resonance Imaging as a Cancer Biomarker: Consensus and Recommendations. In Neoplasia (Vol. 11, Issue 2, pp. 102–125). Elsevier BV. https://doi.org/10.1593/neo.81328
SOCIETY DATA COLLECTIONS
RSNA QIBA AND NCI (RIDER and IRAT)
- Multi Site DCE MRI phantom studies using a modified ADNI phantom ( https://adni.loni.usc.edu/adni-search/?q=phantom )
- http://www.rsna.org/QIBA/
OTHER FEDERAL AGENCIES
FDA CDRH: Partly funded by NCI and NIBIB
NIST
- The National Institute of Standard and Technology has NCI National Biological Imaging Archive data and data from other data sources.
- See Biochange 2008.
- http://www.itl.nist.gov/iad/894.05/biochange2008/Biochange2008-webpage.htm
RIDER Pilot (2005-2007)
This data collection was originally supported under supplemental funding for the Lung Image Database Consortium (LIDC) U01 project and focused on the collection of longitudinal studies using X-ray CT for monitoring the response to therapy. The data came primarily from the M.D. Anderson Cancer Center and several of the LIDC academic sites. The data is not annotated. A small subset of the RIDER Pilot data (8 subjects) which were analyzed in QIBA VolCT Group 1B Round 2 No Change Size Measurements (QIBA-VolCT-1B) have been re-released on TCIA.
Pilot Statistics | |
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Modalities | CR, CT, DX |
Number of Participants | 322 |
Number of Studies | 1,779 |
Number of Series | 4,930 |
Number of Images | 384,535 |