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The MRI data consist of diffusion-weighted images (DWIs), dynamic contrast-enhanced (DCE) images, and multi-flip data for T1-mapping. The MRIs were obtained using a dedicated 16-channel bilateral breast coil at 3.0T (Philips Achieva with the MammoTrak table). DWIs were acquired with a single-shot spin echo (SE) echo planar imaging (EPI) sequence in three orthogonal diffusion encoding directions (x, y, and z). For 14 patients, b = 0 and 500 s/mm2, TR/TE = 2500 ms/45 ms  ms Δ = 21.4 ms,   δ = 10.3 ms and 10 signal acquisitions were acquired. For 19 patients, b = 0 and 600 s/mm2, TR/TE = “shortest” (range = 1800 - 3083 ms/43 - 60 ms)   Δ = 20.7 - 29 ms,   δ = 11.4 - 21 ms and 10 signal acquisitions were acquired. For four patients, b = 50 and 600 s/mm2 for two patients), TR/TE = “shortest” (range = 1840 - 3593 ms/43 - 60 ms)   Δ = 20.6 - 29 ms,   δ = 11.5 - 21 ms and 10 signal acquisitions were acquired. Prior to the DCE-MRI acquisition, data for constructing a T1 map were acquired with an RF-spoiled 3D gradient echo multi-flip angle approach with ten flip angles from 2 to 20 degrees in 2o increments. For both the T1 map and DCE scans, TR = 7.9 ms, TE = 4.6 ms, and the acquisition matrix was 19219220 192x192x20 (full-breast) over a sagittal square field of view (22 cm2) with slice thickness of 5 mm. For the DCE study, each 20-slice set was collected in 16 seconds at 25 time points for just under seven minutes of dynamic scanning. A catheter placed within an antecubital vein delivered 0.1 mmol/kg (9 – 15 mL, depending on patient weight) of gadopentetate dimeglumine, Gd-DTPA, (Magnevist, Wayne, NJ) at 2 mL/sec (followed by a saline flush) via a power injector (Medrad, Warrendale, PA) after the acquisition of the first three dynamic scans (baseline).

Results from a subset of datasets data sets from this collection have been published (see below). If your use of this collection results in a publication, we would appreciate if you cite the appropriate references and acknowledge the award that supported collection and sharing of this dataset (U01 CA142565, PI Thomas E. Yankeelov).

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