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According to the TCGA page on BLCA, TCGA researchers have:

• Identified known and novel molecular alterations in urotheilial bladder carcinoma, locating potential therapeutic targets in 69 percent of the tumors studied
• • The receptor tyrosine kinase (RTK)/RAS pathway involved in cell cycle signaling was altered in 44 percent of tumors
  • TP53, a tumor suppressor in the p53 signaling pathway was mutated in 49 percent of tumors and functionality inactive in 76 percent of cases
  • Her2, a mutation characteristic of some breast cancers, was frequently mutated, suggesting that a subset of urothelial bladder carcinomas may respond to Her2-specific breast cancer treatments
  • Genes involved in regulating chromatin, the structure of DNA and proteins that makes up chromosomes, were frequently mutated and represent novel targets for bladder cancer
• Corroborated the previously observed association between smoking and bladder cancer, as 72 percent of tumors were from patients with a history of tobacco smoking
  • The genomic profiles of smokers were not distinct from those of nonsmokers

Read the full Nature paper about the TCGA-BLCA study.  Additional TCGA publications can be found at: http://cancergenome.nih.gov/publications.

Research and Publications

Per TCGA and TCIA Guidelines, formal permission requests are still required to submit publications using TCGA-BLCA data.  Please see the following links for more information about the freedom-to-publish criteria for these data sets:

Please contact us at help@cancerimagingarchive.net if you have any questions about these policies.

TCGA-BLCA Marker Paper and Image Source Sites (ISS)

Imaging Source Site (ISS) Groups will be populated are being formed and governed by participants from institutions that have provided imaging data to the archive for a given cancer type. Modeled after TCGA analysis groups, ISS groups are given the opportunity to publish a marker paper for a given cancer type per the guidelines in the table above. This opportunity will generate increased participation in building these multi-institutional data sets as they become an open community resource. Current The Cancer Genome Atlas Urothelial Bladder Carcinoma Collection (TCGA-BLCA) source sites include:

• Barretos Cancer Hospital, Barretos, São Paulo, Brazil (pending)
• Baylor College of Medicine (pending)
• MD Anderson Cancer Center (pending)
• Memorial Sloan Kettering Cancer Center (pending)
• University of Chicago (pending)
• University of North Carolina (pending)
• University of Pittsburgh (pending)
• University of Sheffield (pending)

Please contact Dr. Seth Lerner (slerner@bmcslerner@bmc.edu) if you have scientific questions or are interested in collaborating with their group.

Publications

TCGA Bladder Phenotype Research Group Publications

• Seth P. Lerner, Vinay Duddalwar, Erich Huang, Ersan Altun, Tharakeswara Bathala, Steven Kennish, Juan Ibarra, Fabiano Lucchesi, Valdair Francisco Muglia, Stephen Thomas, Raghu Vikram, Hebert Alberto Vargas, Steven Yong Cen, Darryl Hwang, Kevin George King, Bino Varghese, Brenda Fevrier-Sullivan, Justin Kirby, Carl Jaffe, and John Freymann. Comprehensive radiogenomics analysis of qualitative and quantitative features of cross-sectional imaging in the TCGA project in MIBC. Journal of Clinical Oncology 2019 37:7_suppl, 482-482. doi: 10.1200/JCO.2019.37.7_suppl.482 (link)

• Vinay Duddalwar, Seth Lerner, Erich Huang, Bino Varghese, Kevin King, Steven Cen, Darryl Hwang, Ersan Altun, Tharakeswara Bathala, Steven Kennish, Juan Ibarra Rovira, Fabiano Lucchesi, Valdair Francisco Muglia, Stephen Thomas, Raghu Vikram, Hebert Alberto Vargas, Brenda Fevrier-Sullivan, Justin Kirby, Carl Jaffe, and John Freymann. Associations between genetic pathways and radiomic metrics in muscle-invasive bladder cancer. Journal of Urology 2019. 201:4_suppl, e441-e442. doi.org/10.1097/01.JU.0000555889.35481.d4 (link)

Publications written by other members of the research community can be found on our TCIA Publications page.  Please contact us at help@cancerimagingarchive.net if you have a publication you would like us to add.

TCGA Genomics Publications

 Read the Nature paper about the TCGA-BLCA genomic study.  Additional TCGA publications can be found at: http://cancergenome.nih.gov/publications.

Publication Policies

Per TCGA and TCIA Guidelines, formal permission requests are no longer required to submit publications using TCGA-BLCA data.  Please see the following links for more information about the freedom-to-publish criteria for these data sets:

Please contact us at help@cancerimagingarchive.net if you have any questions about these policies.