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| Accurate pre-therapeutic imaging of the tumour and regional lymph nodes, is - in addition to clinical examination and assessment for distant metastases -essential for prognostication and guiding treatment. There is, however, currently a lack of consensus as to which staging modality should be considered as the gold standard for local staging of the tumour (T) and detection of lymph node involvement (N) Local and international guidelines (NCCN, ESMO/ESTRO) vary. On the other hand, nodal staging Nodal staging has been validated as an important independent prognostic factor in anal cancer [EORTC22861; RTOG9811] and the nodal stage as well as the precise location of involved lymph nodes (mesorectum, presacral space, internal iliac lymph nodes, external iliac lymph nodes, ischiorectal fossa, inguinal lymph nodes) has significant bearing on informs the planning of radiotherapy treatment especially when using more conformal techniques such as intensity modulated radiotherapy. Therefore it It is therefore essential that to optimize and standardize pre-treatment staging is optimised and standardised imaging to provide accurate and reproducible information to guide treatment decision, development of radiotherapy atlases and clinical trial design.Whereas there currently exist a lack of consensus as to which staging modality should be considered as the gold standard for local staging of the tumour (T) and detection of lymph node involvement (N), the use of multi-parametric Magnetic Resonance Imaging (MRI) of the pelvis has been endorsed by international guidelines (NCCN, ESMO/ESTRO). An expert panel of radiologist and radiation oncologists specialising with expertise in anal cancer diagnosis and treatment identified by the Anal Staging Subgroup of the International Rare Cancer Incentive (IRCI) will be invited to participate. The panellists panelists will be assigned into groups based on the geographical location and local practice. Each panellist panelist will be provided with access to a series of anonymised anonymized MRI datasets of patients with newly diagnosed anal cancer ; either a combination of contrast enhanced computed tomography (CT) of the pelvis and Positron Emission Tomography (PET)/CT scans (Cases A1-30) OR a combination of contrast enhanced computer tomography (CT) of the pelvis and Magnetic Resonance Imaging (MRI) of the pelvis (Cases B1-30) and asked to provide a TNM stage as well as to identify sites of involved nodes (using a standardised proforma – Appendix1). Each case was selected for the presence of MRI sequences like these: - T2w TSE sagittal [T2-w sagittal turbo spin echo (TSE) sequence covering the pelvis]
- T1w TSE axial [sequence for pelvic nodal detection]
- T2-w TSE axial [sequence of the pelvis]
- T2w TSE sFOV [high-resolution small-field-of-view T2-w TSE sequences perpendicular and parallel to the anal canal]
- DWI [single shot spin echo-echo planar imaging DWI]
- ADC parametric map [apparent diffusion coefficient (ADC) maps]
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Acknowledgements
We would like to acknowledge the individuals and institutions that have provided data for this collection:
- Guy’s and St Thomas’ Hospital in London, United Kingdom
- Special thanks to Dr Kasia Owczarczyk, MD
Hospital/Institution Name city, state, country - Special thanks to First Last Names, degree PhD, MD, etc xxxxxx, Additional Names from same location.Continue with any names from additional submitting sites if collection consists of more than one.- Radiotherapy,
- Adrian Green, Dr Davide Prezzi and Professor Vicky Goh, from the Department of Cancer Imaging
- Professor Richard Adams, Velindre Cancer Centre, Cardiff, Wales
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title | Data Access |
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| Data AccessThis is a limited access data set. If you are an investigator on this project, to request access to ExACT data, please contact help@cancerimagingarchive.net. Data Type | Download all or Query/Filter | License |
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Images,(DICOM, | XXX 6 GB) |
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url | https://wiki.cancerimagingarchive.net/download/attachments/140312582/ExACT%20January%202023.tcia?api=v2 |
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label | Search |
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url | https://nbia.cancerimagingarchive.net/nbia-search/?MinNumberOfStudiesCriteria=1&CollectionCriteria=ExACT |
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(Download requires NBIA Data Retriever) | tcia-cc-by-4 | Clinical data (CSV) | Please contact help@cancerimagingarchive.net to request access to ExACT clinical data. | | Proforma for project panelists (fillable pdf, 575 kB) |
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url | https://wiki.cancerimagingarchive.net/download/attachments/140312582/Anal%20Cancer%20Staging%20Consensus%20Form.pdf?api=v2 |
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Click the Versions tab for more info about data releases. Additional Resources for this DatasetThe following external resources have been made available by the data submitters. These are not hosted or supported by TCIA, but may be useful to researchers utilizing this collection. Appendix - staging criteria- Suggested DICOM viewers for measurements: :
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title | Detailed Description |
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| Detailed DescriptionImage Statistics | Radiology Image StatisticsPathology Image Statistics |
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Modalities | MR | Number of Patients | 30 | Number of Studies | 30 | Number of Series | 179 | Number of Images | 6,400 | Images Size (GB) | 1.6 |
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title | Citations & Data Usage Policy |
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| Citations & Data Usage Policy Tcia limited license policy |
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Please contact help@cancerimagingarchive.net to request access. Info |
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| Authors: Dr. Katarzyna (Kasia) Owczarczyk ;Owczarczyk K., Prezzi D.; Dorothee Boisfwr ; Richard Adams ;Dr. Vicky Goh ; Title: ExACt study: , Boisfwr D., Adams, R., Goh, V. (2023) Expert Anal Cancer Consensus Staging DOI: <coming soon> License: Assume International Attribution by CC 4.0 Creative commons | Info |
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title | Publication Citation |
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| We ask on the proposal form if they have ONE traditional publication they'd like users to cite. (ExACT) [Dataset]. The Cancer Imaging Archive. https://doi.org/10.7937/2023.na2x-j031 |
Info |
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| Clark, K., Vendt, B., Smith, K., Freymann, J., Kirby, J., Koppel, P., Moore, S., Phillips, S., Maffitt, D., Pringle, M., Tarbox, L., & Prior, F. (2013). The Cancer Imaging Archive (TCIA): Maintaining and Operating a Public Information Repository. In Journal of Digital Imaging (Vol. 26, Issue 6, pp. 1045–1057). Springer Science and Business Media LLC. https://doi.org/10.1007/s10278-013-9622-7 |
Other Publications Using This DataTCIA maintains a list of publications which that leverage TCIA data. If you have a manuscript you'd like to add please contact the TCIA Helpdesk. |
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| Version X 1 (Current): Updated yyyy2023/mm03/dd30Data Type | Download all or Query/Filter | License |
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Images (DICOM , XX1.X 9 GB) |
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url | https://wiki.cancerimagingarchive.net/download/attachments/140312582/ExACT%20January%202023.tcia?api=v2 |
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label | Search |
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url | https://nbia.cancerimagingarchive.net/nbia-search/?MinNumberOfStudiesCriteria=1&CollectionCriteria=ExACT |
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(Download requires the NBIA Data Retriever) | tcia-cc-by-4TCIA Restricted | Clinical data (CSV) | Please contact help@cancerimagingarchive.net to request access to ExACt clinical data.
| | Proforma for project panelists (fillable pdf) |
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url | https://wiki.cancerimagingarchive.net/download/attachments/140312582/Anal%20Cancer%20Staging%20Consensus%20Form.pdf?api=v2 |
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