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The Reference Image Database to Evaluate Therapy Response (RIDER) is a targeted data collection used to generate an initial consensus on how to harmonize data collection and analysis for quantitative imaging methods applied to measure the response to drug or radiation therapy. The long term goal is to provide a resource to permit harmonized methods for data collection and analysis across different commercial imaging platforms to support multi-site clinical trials, using imaging as a biomarker for therapy response. Thus, the database should permit an objective comparison of methods for data collection and analysis as a national and international resource as described in |
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the first RIDER white |
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paper report (2006) |
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All the image data are DICOM compliant. The data collection has two phases as described below, which have resulted in several distinct image Collections.
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- Repeat CT Measurements: Human subjects: Lung.
- Download the related lesion notes: MSKCC RepeatCT Lesion notes for RIDER.xls.
- Download the related publication: Evaluating Variability in Tumor Measurements from Same-day Repeat CT Scans of Patients with Non–Small Cell Lung Cancer, 2009.
- 2012-10-18 Update: It was brought to our attention that the RIDER-8509201188 patient contained 2 identical image series rather than the correct secondary/repeat series. The duplicate series has been removed (UID: 1.3.6.1.4.1.9328.50.1.64033480205396366773922006817138551096), but we are unable to obtain the correct series at this point.
Lung CT Statistics | Updated 11/14/2013 |
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Modalities | CT |
Number of |
Participants | 32 |
Number of Studies | 46 |
Number of Series | 63 |
Number of Images | 15,419 |
Images Size (GB) | 7.55 |
RIDER Phantom PET-CT: UNIVERSITY OF WASHINGTON
- Repeat measurements: PET/CT phantoms.
- Consists of repeat measurement PET/CT phantom scan collections carried out under the aegis of the Society of Nuclear Medicine (SNM) to discern the uniformity of clinical imaging instrumentation at various sites. They were obtained in cooperation with SNM as a resource for increased quantitative understanding of machine acquisition, analytic reproducibility and image processing.
- 2015-01-26 Update: Additional annotation data about this collection can be viewed in the following document: Ge68Phantom_2015.doc.
Phantom PET-CT Collection Statistics |
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Modalities | CT, PT |
Number of |
Participants | 20 |
Number of Studies | 20 |
Number of Series | 60 |
Number of Images | 2,231 |
Images Size (MB) | 689 |
RIDER Lung PET-CT: UNIVERSITY OF WASHINGTON
- Longitudinal PET/CT human studies: Lung.
- 2012-02-22 Update: It was brought to our attention that RIDER-1817358092 and RIDER-2617411955 appeared to be the same patient. We have gone back to University of Washington and confirmed this is to be true. For now, we will leave both patients ID in place but plan to eventually delete RIDER-1817358092. RIDER-2617411955 contains some additional series not found in the other patient ID and is what we would advise users to utilize in their research.
Lung PET CT Statistics | Updated 11/14/2013 |
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Modalities | CT, PT |
Number of |
Participants | 244 |
Number of Studies | 275 |
Number of Series | 1349 |
Number of Images | 269,511 |
Images Size (GB) | 78.7 |
RIDER NEURO MRI: DUKE UNIVERSITY
- Repeat human subject studies: Neuro,
- Dynamic Contract Enhanced studies: DCE MRI.
- Diffusion weighted imaging: DWI MR.
- Diffusion tensor imaging: diffusion tensor (DT) MRI.
Neuro MRI Statistics |
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Modalities | MR |
Number of |
Participants | 19 |
Number of Studies | 108 |
Number of Series | 368 |
Number of Images | 70,220 |
Images Size (GB) | 7.3 |
RIDER Breast MRI: UNIVERSITY OF MICHIGAN
- Repeat measurements: Human subjects: Breast.
- DCE MRI.
- ISMRM 2009 poster demonstrates how each of the "coffee break" exams were used as an estimate of each patient's null hypothesis, i.e. distribution associated with no change, and thus supports the estimate of the nulls 97.5 percentile for subsequent estimation of early response to neoadjuvant chemotherapy on an individual patient basis.
Breast MRI Statistics | Updated 2011/11/08 |
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Modalities | MR |
Number of |
Participants | 5 |
Number of Studies | 10 |
Number of Series | 40 |
Number of Images | 1500 |
RIDER PHANTOM MRI: MDACC
- Repeat measurement: Phantom studies.
- DCE MRI.
- RIDER_MR_Phantom_Data_Summary.pdf provides a summary of the images in this collection.
- RIDER_PhantomMR_Key.pdf provides a key for understanding their presentation in NBIA.
Phantom MRI Statistics |
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Modalities | MR |
Number of |
Participants | 10 |
Number of Studies | 13 |
Number of Series | 45 |
Number of Images | 7,061 |
Images Size (GB) | 3.4 |
ACADEMIC SITE COLLECTIONS: Focus on harmonized methods for data collection
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- Repeat measurements.
- DWI
- Phantom measurements.
- Human subjects.
- White Paper: http://www.neoplasia.com/pdf/manuscript/v11i02/neo081328.pdf.Padhani, A. R., Liu, G., Mu-Koh, D., Chenevert, T. L., Thoeny, H. C., Takahara, T., Dzik-Jurasz, A., Ross, B. D., Van Cauteren, M., Collins, D., Hammoud, D. A., Rustin, G. J. S., Taouli, B., & Choyke, P. L. (2009). Diffusion-Weighted Magnetic Resonance Imaging as a Cancer Biomarker: Consensus and Recommendations. In Neoplasia (Vol. 11, Issue 2, pp. 102–125). Elsevier BV. https://doi.org/10.1593/neo.81328
SOCIETY DATA COLLECTIONS
RSNA QIBA AND NCI (RIDER and IRAT)
- Multi Site DCE MRI phantom studies using a modified ADNI phantom ( httphttps://wwwadni.loni.uclausc.edu/ADNI/adni-search/?q=phantom )
- http://www.rsna.org/QIBA/
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This data collection was originally supported under supplemental funding for the Lung Image Database Consortium (LIDC) U01 project and focused on the collection of longitudinal studies using X-ray CT for monitoring the response to therapy. The data came primarily from the Mthe M.D. Anderson Cancer Center and several of the LIDC academic sites. The data is not annotated and is not hosted in The Cancer Imaging Archive but can be downloaded from the NBIA. A small subset of the RIDER Pilot data (8 subjects) which were analyzed in QIBA VolCT Group 1B Round 2 No Change Size Measurements (QIBA-VolCT-1B) have been re-released on TCIA.
Pilot Statistics |
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Modalities | CR, CT, DX |
Number of |
Participants | 322 |
Number of Studies | 1,779 |
Number of Series | 4,930 |
Number of Images | 384,535 |