Summary
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For this study, 1820 lung cancer patients underwent exhale/inhale breath hold CT (BHCT), free-breathing four-dimensional CT (4DCT) and Galligas PET ventilation scans in a single session on a combined 4DPET/CT scanner. The purpose of the study was to enable comparisons between: (i) CT ventilation images derived from exhale/inhale BHCT scans, (ii) CT ventilation images derived from free-breathing 4DCT scans, and (iii) Galligas PET (nuclear medicine) ventilation scans. This dataset can build the international capacity for prototyping and evaluating new CT ventilation imaging technologies. 20 4DCT scans, 1620 inhale/exhale BHCT scans and 18, 20 Galligas PET scans and 19 attenuation CT scans (missing for CT-PET-VI-07) were successfully acquired for the 1820 patients and included in this dataset. Real World Value Mapping files generated with the PET scans have been included. This DICOM file type is normally used to convert activity to estimated tissue uptake Standardized Uptake Values (SUVs) assuming tissue density of 1g/mL. However, for this study radiotracer was not injected intravenously into tissue, but inhaled into the lung where this assumption does not hold, so these files should be used with caution This study was a prospective single institution clinical trial approved by the health district ethics committee, (HREC/12/169) and registered with the Australian New Zealand Clinical Trials Registry (ACTRN12612000775819). The following are known limitations of this dataset:
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Acknowledgements
This work was supported by an NHMRC Australia Fellowship and a Cancer Institute NSW Early Career Fellowship. The authors thank the staff from the Royal North Shore Hospital’s Nuclear Medicine, Radiation Oncology and Respiratory Medicine Departments. Our thanks and gratitude go to the patients who volunteered their time to participate in this study.
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