Summary
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location | https://www.cancerimagingarchive.net/collection/qin-breast/ |
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This collection contains longitudinal PET/CT and quantitative MR images collected for the purpose of studying treatment assessment in breast cancer in the neoadjuvant setting. Images were acquired at three time points: prior to the start of treatment (t1), after the first cycle of treatment (t2), and either after the second cycle of treatment or at the completion of all treatments (prior to surgery) (t3). The PET/CT images were acquired with a support device built in-house to allow the patient to be in the prone position to facilitate registration with the MRI data. The value of this collection is to provide clinical imaging data for the development and evaluation of quantitative imaging methods for treatment assessment early in the course of therapy for breast cancer. Data is provided by Vanderbilt University, PI Dr. Thomas E. Yankeelov. |
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The MRI data consist of diffusion-weighted images (DWIs), dynamic contrast-enhanced (DCE) images, and multi-flip data for T1-mapping. The MRIs were obtained using a dedicated 16-channel bilateral breast coil at 3.0T (Philips Achieva with the MammoTrak table). DWIs were acquired with a single-shot spin echo (SE) echo planar imaging (EPI) sequence in three orthogonal diffusion encoding directions (x, y, and z). For 14 patients, b = 0 and 500 s/mm2, TR/TE = 2500 ms/45 ms Δ = 21.4 ms, δ = 10.3 ms and 10 signal acquisitions were acquired. For 19 patients, b = 0 and 600 s/mm2, TR/TE = “shortest” (range = 1800 - 3083 ms/43 - 60 ms) Δ = 20.7 - 29 ms, δ = 11.4 - 21 ms and 10 signal acquisitions were acquired. For four patients, b = 50 and 600 s/mm2 for two patients), TR/TE = “shortest” (range = 1840 - 3593 ms/43 - 60 ms) Δ = 20.6 - 29 ms, δ = 11.5 - 21 ms and 10 signal acquisitions were acquired. Prior to the DCE-MRI acquisition, data for constructing a T1 map were acquired with an RF-spoiled 3D gradient echo multi-flip angle approach with ten flip angles from 2 to 20 degrees in 2o increments. For both the T1 map and DCE scans, TR = 7.9 ms, TE = 4.6 ms, and the acquisition matrix was 192x192x20 (full-breast) over a sagittal square field of view (22 cm2) with slice thickness of 5 mm. For the DCE study, each 20-slice set was collected in 16 seconds at 25 time points for just under seven minutes of dynamic scanning. A catheter placed within an antecubital vein delivered 0.1 mmol/kg (9 – 15 mL, depending on patient weight) of gadopentetate dimeglumine, Gd-DTPA, (Magnevist, Wayne, NJ) at 2 mL/sec (followed by a saline flush) via a power injector (Medrad, Warrendale, PA) after the acquisition of the first three dynamic scans (baseline).
QIN-Breast-02 Multi-center Study
An extension of this QIN-BREAST collection is available via the QIN-BREAST-02 collection. It contains updated scan protocols and data collected at both Vanderbilt University Medical Center and the University of Chicago to demonstrate similar results at multiple sites (both using Philips 3T MR scannersResults from a subset of data sets from this collection have been published (see below). If your use of this collection results in a publication, we would appreciate if you cite the appropriate references and acknowledge the award that supported collection and sharing of this dataset (U01 CA142565, PI Thomas E. Yankeelov).
About the NCI QIN
The mission of the QIN is to improve the role of quantitative imaging for clinical decision making in oncology by developing and validating data acquisition, analysis methods, and tools to tailor treatment for individual patients and predict or monitor the response to drug or radiation therapy. More information is available on the Quantitative Imaging Network Collections page. Interested investigators can apply to the QIN at: Quantitative Imaging for Evaluation of Responses to Cancer Therapies (U01) PAR-11-150.
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title | Data Access |
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Imaging Data
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This is a limited access data set. To request access, please contact help@cancerimagingarchive.net. Once access is granted, you can view and download these images on The Cancer Imaging Archive (TCIA) by logging in and selecting the QIN-Breast collection. |
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Collection Statistics
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Data AccessData Type | Download all or Query/Filter | License |
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Images (DICOM, 11.286 GB) |
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url | https://wiki.cancerimagingarchive.net/download/attachments/18513974/QIN-BREAST_2015-09-04.tcia?version=1&modificationDate=1542735424249&api=v2 |
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url | https://www.cancerimagingarchive.net/nbia-search/?CollectionCriteria=QIN-Breast |
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(Download requires the NBIA Data Retriever) | | QIN-Breast Treatment Response (XLS, 16 kB) |
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url | https://wiki.cancerimagingarchive.net/download/attachments/18513974/QIN-Breast_TreatmentResponse%282014-12-16%29.xlsx?version=1&modificationDate=1418736971268&api=v2 |
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Click the Versions tab for more info about data releases. Nci_crdc additional resources |
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title | Detailed Description |
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| Detailed Description |
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Modalities
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If you are unsure how to download this collection, please view Searching by Collection or refer to our TCIA's User's Guide for more detailed instructions on using the site.
Related Peer Reviewed Manuscripts
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title | Citations & Data Usage Policy |
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| Citations & Data Usage Policy Tcia limited license policy |
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| Li, X., Abramson, R. G., Arlinghaus, L. R., Chakravarthy, A. B., Abramson, V. G., Sanders, M., & Yankeelov, T. E. (2016). Data From QIN-Breast (Version 2) [Data set]. The Cancer Imaging Archive. https://doi.org/10.7937/K9/TCIA.2016.21JUEBH0 |
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title | Funding Acknowledgement |
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| Please be sure to acknowledge the award that supported collection and sharing of this dataset (U01 CA142565, PI Thomas E. Yankeelov). |
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title | Publication citation: |
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| Li X, Abramson RG, Arlinghaus LR, Kang H, Chakravarthy AB, Abramson VG, Farley J, Mayer IA, Kelley MC, Meszoely IM, Means-Powell J, Grau AM, Sanders M, |
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Multiparametric magnetic resonance imaging for predicting pathological response after the first cycle of neoadjuvant chemotherapy in breast cancer. Investigative Radiology, 2015 Apr;50(4): |
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| Clark K, Vendt B, Smith K, Freymann J, Kirby J, Koppel P, Moore S, Phillips S, Maffitt D, Pringle M, Tarbox L, Prior F. The Cancer Imaging Archive (TCIA): Maintaining and Operating a Public Information Repository, Journal of Digital Imaging, Volume 26, Number 6, December, 2013, pp 1045-1057. DOI: 10.1007/s10278-013-9622-7 |
Other Publications Using This DataTCIA maintains a list of publications which leverage TCIA data. If you have a manuscript you'd like to add please contact TCIA's Helpdesk. |
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| Version 2 (Current): Updated 2020/01/10Lifted "Restricted access" embargo. No changes to files were required. Version 1: Updated 2015/09/04Data Type | Download all or Query/Filter |
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Images (DICOM, 11.286GB) |
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url | https://wiki.cancerimagingarchive.net/download/attachments/18513974/QIN-BREAST_2015-09-04.tcia?version=1&modificationDate=1542735424249&api=v2 |
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label | Search |
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url | https://www.cancerimagingarchive.net/nbia-search/?CollectionCriteria=QIN-Breast |
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(Download requires the NBIA Data Retriever.) | QIN-Breast Treatment Response (XLS) |
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url | https://wiki.cancerimagingarchive.net/download/attachments/18513974/QIN-Breast_TreatmentResponse%282014-12-16%29.xlsx?version=1&modificationDate=1418736971268&api=v2 |
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