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Comment: Minor grammatical corrections, and added paragraph about certificate warnings on Macs.

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Java version 6 or higher of the Java Runtime Environment (JRE) must be installed to be able to open the Download Manager. See Chapter 3 of the TCIA User's Guide for more information.

On some systems, notably later versions of the Mac OS X, the system may not recognize the Certificate Authority that The Cancer Imaging Archive uses to protect content from the web site transmitted via the https protocol and to sign Java Web Start applications, such as the Download Managers.  In these cases, Java may give a certificate warning, asking if you really trust this site enough to run the program.  In all cases, newer versions of Java will also ask the user if they really want to launch a program that has access to their files.  (Obviously, Download Manager needs such access in order to store downloaded files.) The user must answer in the affirmative (i.e. 'yes, I trust this site' or 'yes, I trust this program' in order for Download Manager to start.  One can avoid the warnings by either putting the cancerimagingarchive.net into "exceptions" list (i.e. trusted sites list) on the security tab in Java's control panel (only available in later versions of Java 7), or lowering the Java security level temporarily to "Medium" (not recommended).

Does Download Manager work with any browser?

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Are there operating system requirements for Download Manager?

In theory, the Download Manager, being Java based, will work on any operating system.  Howevertheory, the Download Manager, being Java based, will work on any operating system.  We have tested on various flavors of the Windows, Linux, and Mac OS X operating systems.  We are fairly confident that the Download manager to run on any of these operating systems; however, the Mac OS X operating system has been imposing additional security requirements on Java Web Start programs, such as the Download Manager, which make it difficult them difficult to run them without having unless the user has administrative access to the Mac.  In particular, the Gatekeeper function in 10.8.4 (Mountain Lion) and later versions of Mac OS X by default blocks starting third party programs that have not been either obtained from the Apple App store, or that have not been signed with an Apple Developer ID.  This includes, naturally, Java Web Start programs such as the Download Manager.  To get around this restriction, one can either change the default Gatekeeper setting, found in the Security tab of Apple System Preferences, to allow the running of 3rd party applications, or download the JNLP file used to launch the Download Manager, and then command | control | right click the JNLP file and select "Run" from the pop-up context menu.  Double clicking the JNLP file will not work with the default security settings on the later versions of Mac OS X.  Note that either method requires either having administrative access to the Mac OS, or knowing the username/password of an administrator account, since the Mac will prompt for this information.

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