Acknowledgements
This shared data set was provided by the Breast Imaging Research Program at UCSF, in collaboration with ACRIN (American College of Radiology Imaging Network), the I-SPY TRIAL (Investigation of Serial Studies to Predict Your Therapeutic Response with Imaging and molecular Analysis), and TCIA.
Funding sources include:
| UCSF | R01 CA132870 and U01 CA151235 |
| ACRIN | CA079778 and CA080098 |
| I-SPY | CA31964 and CA33601 |
David Newitt, PhD, UCSF
Nola Hylton, PhD, UCSF
Summary
BACKGROUND
ACRIN 6657 was designed as a prospective study to test MRI for ability to predict response to treatment and risk-of-recurrence in patients with stage 2 or 3 breast cancer receiving neoadjuvant chemotherapy (NACT). ACRIN 6657 was conducted as a companion study to CALGB 150007, a correlative science study evaluating tissue-based biomarkers in the setting of neoadjuvant treatment of breast cancer. Collectively, CALGB 150007 and ACRIN 6657 formed the basis of the multicenter Investigation of Serial Studies to Predict Your Therapeutic Response with Imaging and moLecular Analysis (I-SPY TRIAL) breast cancer trial, a study of imaging and tissue-based biomarkers for predicting response and survivalAdd protocol references for all three studies.
Participant Eligibility and Enrollment: Criteria for inclusion were patients enrolling on CALGB 150007 with T3 tumors measuring at least 3 cm in diameter by clinical exam or imaging and receiving neoadjuvant chemotherapy with an anthracycline-cyclophosphamide regimen alone or followed by a taxane. Pregnant patients and those with ferromagnetic prostheses were excluded from the study. The study was open to enrollment from May 2002 to March 2006. 237 patients were enrolled, of which 230 met eligibility criteria.
...
Collection Statistics | (updated 116/2118/20142015) |
|---|---|
Modalities | MR |
Number of Patients | 222 |
Number of Studies | 847 |
Number of Series | 7920 |
Number of Images | 386878 |
| Images Size (GB) |
If you are unsure how to download this Collection please view our quick guide on Searching by Collection or refer to our The Cancer Imaging Archive User's Guide for more detailed instructions on using the site.
Shared Lists: See descriptions below under "Curated Data Sets"
...
- Longest Diameter (LD) dataset
- Good SER Functional Tumor Volume (FTV) dataset
- ACRIN 6657 Primary Aim Analysis Setdataset
Imaging Data Transfer Process
...
847 MR on-study studies (222 subjects) in UCSF image database.
One patient in the image data collection (I-SPY ID 1079 ) does not appear in the Feb. 2, 2011 I-SPY FINAL LOCKED clinical data set. So no clinical data is available.
| Anchor | ||||
|---|---|---|---|---|
|
Studies with MRI measured longest diameter
839 MR studies have LD reported in the I-SPY 1 clinical database
834 MR studies (219 subjects) in UCSF image database with LD
5 studies that have LD measurement are missing from | ||
|---|---|---|
1071, T1 | 1101, T3 | 1187, T4 |
| Anchor | ||||
|---|---|---|---|---|
|
708 MR studies (208 subjects) in UCSF image database
...
- Patient 1079 does not appear in the Feb. 2, 2011 I-SPY FINAL LOCKED clinical data set. So no clinical data is available.
| Anchor | ||||
|---|---|---|---|---|
|
707 MR studies (207 subjects) in UCSF image database
Differences between Levels 2a and 2b:
...