Abbreviations

Acknowledgements

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Funding sources include:

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Summary

BACKGROUND

ACRIN 6657 was designed as a prospective study to test MRI for ability to predict response to treatment and risk-of-recurrence in patients with stage 2 or 3 breast cancer receiving neoadjuvant chemotherapy (NACT). ACRIN 6657 was conducted as a companion study to CALGB 150007, a correlative science study evaluating tissue-based biomarkers in the setting of neoadjuvant treatment of breast cancer. Collectively, CALGB 150007 and ACRIN 6657 formed the basis of the multicenter Investigation of Serial Studies to Predict Your Therapeutic Response with Imaging and moLecular Analysis (I-SPY TRIAL) breast cancer trial, a study of imaging and tissue-based biomarkers for predicting response and survivalAdd protocol references for all three studies.
Participant Eligibility and Enrollment: Criteria for inclusion were patients enrolling on CALGB 150007 with T3 tumors measuring at least 3 cm in diameter by clinical exam or imaging and receiving neoadjuvant chemotherapy with an  anthracycline-cyclophosphamide regimen alone or followed by a taxane. Pregnant patients and those with ferromagnetic prostheses were excluded from the study. The study was open to enrollment from May 2002 to March 2006. 237 patients were enrolled, of which 230 met eligibility criteria.

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• ACRIN 6657 Protocol http://www.acrin.org/6657_protocol.aspx
• I-SPY TRIAL http://ncicb.nci.nih.gov/tools/translation_research/isp
• CALGB 150007 http://www.cancer.gov/clinicaltrials/search/view?cdrid=69280&version=HealthProfessional
• Data Dictionary

Abbreviations

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Data Access

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Info
This is a limited access data set. To request access, please contact (ACRIN Contact). If access is granted you will be able to view and download these images on The Cancer Imaging Archive (TCIA) by logging in and selecting the I-SPY1 collection. This data set will be made publicly available on or before XXXX XX, 20XX.

Imaging Data

Acknowledgements

This shared data set was provided by the Breast Imaging Research Program at UCSF, in collaboration with ACRIN, the I-SPY TRIAL, and TCIA.

David Newitt, PhD, UCSF, Nola Hylton, PhD, UCSF  

Funding sources include:

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((( END OF PUBLIC PAGE - REST GOES ON SEPARATE PAGE ACCESSIBLE TO THOSE WITH STUDY DOWNLOAD PRIVILEDGES  )))

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If you are unsure how to download this Collection please view our quick guide on view Searching by Collection or refer to our to The Cancer Imaging Archive User's Guide for more detailed instructions on using the site.

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• MRI studies were sent from the study centers to ACRIN Core Lab either via media (DVD) or the TRIAD program
• Image data were de-identified and centrally archived at ACRIN Core Lab
• Archived data was sent to the breast MR imaging laboratory at University of California at San Francisco (UCSF) for volumetric analysis.
• De-identified image data, derived analysis maps and segmentations, and ancillary data files were transferred from UCSF to TCIA for data sharing.

While every effort was made to preserve the integrity of both the original image data and image meta-data (DICOM attributes, public and private), multiple file transfers and strict adherence to HIPPA guidelines for patient confidentiality may have resulted in loss of some data. If any questions arise, or any patient PHI is found in any data on this collection, please contact David Newitt at the Breast Imaging Research Program, UCSF (david.newitt@ucsf.edu). 

Curated Data Sets

Summary

In addition to the complete set of ACRIN 6657 imaging studies, curated data sets based on UCSF QC assessment, protocol compliance and data completeness are provided for download in the form of TCIA shared lists for selective downloads. . These image data sets are accompanied by Excel files with patient clinical and outcome data.

Shared Lists: See descriptions below under "Curated Data Sets"

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