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Summary

A particular emphasis of this project was to study the earliest stages of breast cancer—preinvasive ductal carcinoma in situ (DCIS)—and to interrogate the underlying genetic events that influence progression into invasive disease. In particular, we focused on the role of perturbed Rb, p53 and BRCA1 functionality and how these pathways, acting alone and in combination, can influence the development and progression of DCIS. GEMMs serve as an excellent model system wherein genetic changes can be controlled and manipulated over time.  In vivo MRI is a superb technique for noninvasively tracking and characterizing these microscopic early stage cancers as they develop, change and transition into lethal invasive disease.

For more information, please contact Dr. Sunny Jansen (jansensa0@gmail.com).

Acknowledgements

We would like to acknowledge the individuals and institutions that have provided data for this collection:

• National Cancer Institute (Frederick, Maryland) - Special thanks to Sunny Jansen, PhD  from the Department of Mouse Cancer Genetics Program.

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Localtab Group

Localtab active true title Data Access Data Access Choosing the Download option will provide you with a file to launch the TCIA Download Manager to download the entire collection. If you want to browse or filter the data to select only specific scans/studies please use the Search By Collection option. Data Type Download all or Query/Filter Images (8.6GB) Image Added Image Added Mouse GBM Update (PPT) Image Added Click the Versions tab for more info about data releases. Localtab title Detailed Description Detailed Description Collection Statistics Updated 03/18/2015 Modalities MR Number of Patients 32 Number of Studies 149 Number of Series 205 Number of Images 23,487 Images Size (GB) 8.6   Related Data Mouse GBM:  A Pilot Collection: Sunny_jansen_NBIA_mouseGBM_update_ICR_508.ppt . Localtab title

Citations & Data Usage Policy Citations & Data Usage Policy  This collection is freely available to browse, download, and use for commercial, scientific and educational purposes as outlined in the Creative Commons Attribution 3.0 Unported License.  See TCIA's Data Usage Policies and Restrictions for additional details. Questions may be directed to help@cancerimagingarchive.net. Please be sure to include the following citations in your work if you use this data set: Info title Mouse-Mammary Citation The Cancer Imaging Archive Team. Data From Mouse-Mammary. doi:10.7937/K9/TCIA.2015.QWZMGFZJ Info title TCIA Citation Clark K, Vendt B, Smith K, Freymann J, Kirby J, Koppel P, Moore S, Phillips S, Maffitt D, Pringle M, Tarbox L, Prior F. The Cancer Imaging Archive (TCIA): Maintaining and Operating a Public Information Repository, Journal of Digital Imaging, Volume 26, Number 6, December, 2013, pp 1045-1057. (paper) Other Publications Using This Data Jansen SA et al, NMR Biomed. 2011 Aug;24(7):880-7.  Jansen SA et al, Breast Cancer Res. 2009;11(5):R65.  Jansen SA et al, Radiology. 2009 Nov;253(2):399-406. Jansen SA et al, Phys Med Biol. 2008 Oct 7;53(19):5481-93. DOD Award:  http://oai.dtic.mil/oai/oai?verb=getRecord&metadataPrefix=html&identifier=ADA585341. Jansen SA., Ductile carcinoma in situ: magnetic resonance and ultrasound imaging in mouse models of breast cancer (Mouse.Mammary.MRI.Ultrasound.Summary.pdf). Jansen S., Investigating genetic events in the progression of ductal carcinoma in situ (Mouse.Mammary.Genetics.DCIS.pdf). If you have a publication you'd like to add please contact the TCIA Helpdesk. Localtab title Versions Version 1 (Current): Updated 2015/03/18 Data Type Download all or Query/Filter Images (8.6GB) Image Added Image Added Mouse GBM Update (PPT) Image Added

Data Access

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