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Imaging from each cancer type will be contained in its own TCIA Collection, with the collection name "CPTAC-cancertype".  Radiology imaging is collected from standard of care imaging performed on patients immediately before the pathological diagnosis, and from follow-up scans where available.  For this reason the radiology image data sets are heterogeneous in terms of scanner modalities, manufacturers and acquisition protocols. Pathology imaging is collected as part of the CPTAC qualification workflow.  

All CPTAC cohorts are released as either a single combined cohort, or split into Discovery and Confirmatory where applicable.  There are two main types of proteomic studies: discovery proteomics and targeted proteomics. The term "discovery proteomics" is in reference to "untargeted" identification and quantification of a maximal number of proteins in a biological or clinical sample. The term “targeted proteomics” refers to quantitative measurements on a defined subset of total proteins in a biological or clinical sample, often following the completion of discovery proteomics studies to confirm interesting targets selected. Commonly used proteomic technologies and platforms are different types of mass spectrometry and protein microarrays depending on the needs, throughput and sample input requirement of an analysis, with further development on nanotechnologies and automation in the pipeline in order to improve the detection of low abundance proteins, increase throughput, and selectively reach a target protein in vivo.  Once the protein targets of interest are identified, high-throughput targeted assays are developed for confirmatory studies: tests to affirm that the initial tests were accurate. A summary of CPTAC imaging efforts can be found on the CPTAC Imaging Proteomics page. 

CPTAC Imaging Special Interest Group

You can join the CPTAC Imaging Special Interest Group to be notified of webinars & data releases, collaborate on common data wrangling tasks and seek out partners to explore research hypotheses!  Artifacts from previous webinars such as slide decks and video recordings can be found on the CPTAC SIG Webinars page.

Acknowledgements

We would like to acknowledge the individuals and institutions that have provided data for this collection:

• International Institute for Molecular Oncology, Poznań, Poland - Special thanks to Maciej Wiznerowicz MD, PhD and Jan Lubiński MD PhD; Heliodor Święcicki Clinical Hospital, Poznań, Poland; Witold Szyfter MD, PhD, Malgorzata Wierzbicka MD, PhD., Ewelina Kalinowicz MD and Joanna Napierała
• BioPartners, CA - Special thanks to Alexander Gasparian, PhD.  from the Department of Drug Discovery and Biomedical Sciences, University of South Carolina College of Pharmacy, Kakhaber Zaalishvili, MD  Medical Advisor and Staff Pathologist at BioPartners, LLC, Milla Gorodnia,  President of BioPartners, Inc., Victoria Christensen, Global Business Development/Project Coordination Manager, Oksana Havryliuk, MD. Chief of Research department of radiodiagnostics of NCI (Ukraine), Marianna Gredil’, Director of BioPartners, LLC, and  Anna Legenka Chief of the Data Department at BioPartners, LLC.
• Beaumont Health System, Royal Oak, MI - Special thanks to George D. Wilson, PhD from the Department of Radiation Oncology Research, Barbara Pruetz of the Biobank, Debra Kapczynski, MHSA, CIIP, RT(R)(CT) and Rachel Deyer from the Department of Diagnostic Radiology.
• Boston Medical Center, Boston, MA - Special thanks to Chris D. Andry M.Phil, PhD from the Department of Pathology and Laboratory Medicine, Margaret Lavoye, Artem Kaliaev, Wilson Chavez, Stephan Anderson, Jorge Soto, and Mitchell Horn from the Department of Radiology, Elizabeth Duffy, MA and Cheryl Spencer, MA of the Biobank.
• University of Calgary, Alberta, Canada - Special thanks to Oliver Bathe, MD, FRCS(C) from the Departments of Surgery/Oncology, Marina Salluzzi, PhD and Nicole Blenkin from the Department of Radiology, Calgary Image Processing and Analysis Centre (CIPAC), and Jennifer Koziak and Elleine Allapitan from the Department of Surgery.
• Washington University in St. Louis, Saint Louis, MO - Special thanks to Sidharth V Puram, MD, PhD, Fudong Wang, PhD, Thomas Barrett, MD, Salma Ramadan, MD,  and Sophie Gerndt, MD from the Department of Otolaryngology-Head and Neck Surgery.
• University of Kansas Medical Center – Special thanks to Andrew K. Godwin, PhD and Rashna Madan, MBBS from the Department of Pathology and Laboratory Medicine and Monica Mays, Lauren DiMartino, and Alex Webster from the University of Kansas Cancer Center.
• University of Oklahoma– Special thanks to Kar-Ming Fung, MD, PhD, Director of Anatomic Pathology, David Brown, Assistant Director of Clinical Trials Office, Biospecimen Core Lab, Shawnton Long, Manager of Clinical Trials Office, Tissue Lab, Biospecimen Core Lab, and Myria Reed, RHIA, Project Manager of Clinical Trials Office, Biospecimen Core Lab.
• H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL - Special thanks to John Koomen, Ph.D. from the Department of Molecular Oncology, and Edward R. Seijo, MS and Olya Stringfield, PhD.