Summary

The Reference Image Database to Evaluate Therapy Response (RIDER) database is a targeted data collection for the purpose of generating an initial consensus on how to harmonize data collection and analysis for quantitative imaging methods as applied to measure the response to drug or radiation therapy. The long term goal is to provide a resource to permit harmonized methods for data collection and analysis across different commercial imaging platforms, as required to support multi-site clinical trials, using imaging as a biomarker for therapy response. Thus the database should permit an objective comparison of methods for data collection and analysis as a national and international resource as described in the first RIDER white paper report (2006):

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All the image data are DICOM compliant and the image, annotations and meta data formats meets all the requirements for caBIG and the NBIA.  The data collection has two phases as described below, which have resulted in several distinct image Collections.

RIDER

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This data collection was originally supported under supplemental funding for the LIDC U01 project and focused on the collection of longitudinal studies using X-ray CT for monitoring the response to therapy. The data came primarily from MDACC and several of the LIDC academic sites. The data is not annotated.

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Contracts (2007-Beyond)

NCI has exercised a series of contracts with specific academic sites for collection of repeat "coffee break" and longitudinal phantom and patient data for a range of imaging modalities (currently CT, PET CT, DCE MRI, DW MRI) and organ sites (currently lung, breast, and neuro). The goals are as follows:

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The RIDER project will be replaced when the QIN initiative is fully implemented as this research network will be tasked to create database resources collected from phase 1-3 clinical trials, where clinical outcomes will be included in the meta data: http://grants.nih.gov/grants/guide/pa-files/PAR-11-150.html

ACADEMIC SITE COLLECTIONS: Focus on methods for data analysis

MSKCC

• Images contained in "RIDER Lung CT" Collection
• Repeat CT Measurements: Human subjects: Lung
• Download the related lesion notes: MSKCC RepeatCT Lesion notes for RIDER.xls
• Download the related publication: Zhaob-RepeatCT Radiology2009.pdf

UNIVERSITY OF WASHINGTON

• Images contained in "RIDER Phantom PET-CT" Collection
• Repeat measurements: PET/CT phantoms
• Consists of repeat measurement PET/CT phantom scan collections carried out under the aegis of the Society of Nuclear Medicine (SNM) to discern the uniformity of clinical imaging instrumentation at various sites. They were obtained in cooperation with Society of Nuclear Medicine as a resource for increased quantitative understanding of machine acquisition, analytic reproducibility and image processing.
• Additional annotation data about this collection can be viewed in the following document: Ge68Phantom.doc

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DUKE UNIVERSITY

• Images contained in "RIDER Neuro MRI" Collection
• Repeat human subject studies: Neuro
• Dynamic Contract Enhanced studies: DCE MRI:
• Diffusion weighted imaging: DWI MR
• Diffusion tensor imaging: DT MRI.

UNIVERSITY OF MICHIGAN

• Images contained in "RIDER Breast MRI" Collection
• Repeat measurements: Human subjects: Breast
• DCE MRI
• ISMRM 2009 poster demonstrates how each of the "coffee break" exams were used as an estimate of each patient's null hypothesis, i.e. distribution associated with no change, and thus supports the estimate of the null's 97.5 percentile for subsequent estimation of early response to neoadjuvant chemotherapy on an individual patient basis.

MDACC

• Images contained in "RIDER Phantom MRI" Collection
• Repeat measurement: Phantom studies
• DCE MRI
• RIDER_MR_Phantom_Data_Summary.pdf provides a summary of the images in this collection.
• RIDER_PhantomMR_Key.pdf provides a key for understanding their presentation in NBIA.

ACADEMIC SITE COLLECTIONS: Focus on harmonized methods for data collection

MULTI SITE STUDY (Total of 20 sites): Organized under a contract with the University of Michigan ( Under development: 2009)

• Repeat measurements
• Diffusion Weighted Imaging (DWI)
• Phantom measurements
• Human subjects
• White Paper: http://www.neoplasia.com/pdf/manuscript/v11i02/neo081328.pdf

SOCIETY DATA COLLECTIONS

RSNA QIBA AND NCI (RIDER and IRAT) (2009-beyond: under development)

• Multi Site DCE MRI phantom studies using a modified ADNI phantom (http://www.loni.ucla.edu/ADNI/ )
• http://www.rsna.org/Research/qiba.cfm

OTHER FEDERAL AGENCIES

FDA CDRH: Partly funded by NCI and NIBIB

• Phantom FDA

NIST

• NIST has NCI NBIA data and data from other data sources
• See Biochange 2008
• http://www.itl.nist.gov/iad/894.05/biochange2008/Biochange2008-webpage.htm

RIDER Pilot (2005-2007)

This data collection was originally supported under supplemental funding for the LIDC U01 project and focused on the collection of longitudinal studies using X-ray CT for monitoring the response to therapy. The data came primarily from MDACC and several of the LIDC academic sites. The data is not annotated and is not hosted in TCIA but can be downloaded from the National Biomedical Imaging Archive (NBIA).