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Table 1: Penetrance and location of pathological confirmed metastatic lesion(s).
# animals in Group | # animals that displayed metastasis in MRI and confirmed by Pathology | Pathology confirmation of MRI (primary imaging site) | Other confirmed Location (s) |
10 (non-resected) | 4 (5 mice were EU due to xenograft size prior to observation of metastases) | Lung | Lung |
10 (resected) | 10 | Lung | Lung, Kidney, Nodes, Peritoneal Wall |
Percent penetrance with respect to the average time-to-metastasis for non-resected (plot A: time from implant) and resected (plot B: time from tumor resection) cohorts.
Plot A |
Plot B |
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PET/CT Characterization of the primary tumor: Baseline PET (SOP available below) were performed when tumor reached an approximate 200 mm3. Average SUVmax values (n=5) were calculated; [18F]FDG: 1.3 ± 0.2 and [18F]FLT: 2.3 ± 0.6.
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