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Percent penetrance with respect to the average time-to-metastasis for non-resected (plot A: time from implant) and resected (plot B: time from tumor resection) cohorts.
 Plot A |
Plot B |
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PET/CT Characterization of the primary tumor: Baseline PET (SOP attached) were performed when tumor reached an approximate 200 mm3. Average SUVmax values (n=5) were calculated; [18F]FDG SUVmax: 4.4 ± 0.6
Baseline PET and [18F]FLT SUVmax: 1.3 ± 0.3.
Conclusion:
Excellent metastatic model with at least 60% penetrance non-resected and 100% with planned resection. Metastases well observed on T2 MRI imaging allowing non-invasive evaluation in treatment trials. This model can be challenging in a drug study due to the rapid xenograft tumor growth and re-growth after tumor excision.
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