Summary
4D-FBCT images were acquired on a 16-slice helical CT scanner (Brilliance Big Bore, Philips Medical Systems, Andover, MA) as respiration-correlated CTs with 10 breathing phases (0 to 90%, phase-based binning) and 3 mm slice thickness. 4D-FBCT images were acquired during simulation, prior to therapy, and used for therapy planning. In 14 of the 20 subjects, 4D-FBCTs were also acquired on the same scanner weekly during therapy. 4D-CBCT images were acquired on a commercial CBCT scanner (On-Board Imager™, Varian Medical Systems, Inc.). An external surrogate (Real-time Position Management, Varian Medical Systems, Inc.) was integrated into the CBCT acquisition system to stamp each CBCT projection with the surrogate respiratory signal through in-house software and hardware tools. Approximately 2500 projections were acquired over a period of 8-10 minutes in half-fan mode with half bow-tie filter. The technique was 125 kVp, 20 mA, and 20 ms in a single 360° slow gantry arc. Using the external surrogate, the CBCT projections were sorted into 10 breathing phases (0 to 90%, phase-based binning) and reconstructed with an in-house FDK reconstruction algorithm.
Audio-visual biofeedback was performed for all 4D-FBCT and 4D-CBCT acquisitions in all subjects. A single Radiation Oncologist delineated targets and organs at risk in all 4D-FBCT and a limited number of 4D-CBCT images, on all 10 phases per scan. Seven of the subjects had gold coils implanted as fiducial markers in or near the tumor.
The dataset is most fully described in detail in Balik et al.1 Seven of the subjects had gold coils implanted as fiducial markers in or near the tumor. The implantation procedure and details of marker location are described in detail in Roman et al.2
References
Acknowledgements
Data collection and analysis was supported by NIH P01CA116602.
Data Access
| Data Type | Download all or Query/Filter | License |
|---|---|---|
| Images and Radiation Therapy Structures (DICOM, 183GB) | (Download requires NBIA Data Retriever) |
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Additional Resources for this Dataset
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- Imaging Data Commons (IDC) (Imaging Data)
Detailed Description
Collection Statistics | |
|---|---|
Modalities | CT, RTSTRUCT |
Number of Participants | 20 |
Number of Studies | 589 |
Number of Series | 6,690 |
Number of Images | 347,330 |
| Image Size (GB) | 183 |
Citations & Data Usage Policy
Users must abide by the TCIA Data Usage Policy and Restrictions. Attribution should include references to the following citations:
Data Citation
Hugo, G. D., Weiss, E., Sleeman, W. C., Balik, S., Keall, P. J., Lu, J., & Williamson, J. F. (2016). Data from 4D Lung Imaging of NSCLC Patients (Version 2) [Data set]. The Cancer Imaging Archive. https://doi.org/10.7937/K9/TCIA.2016.ELN8YGLE
Publication Citation
Hugo, G. D., Weiss, E., Sleeman, W. C., Balik, S., Keall, P. J., Lu, J., & Williamson, J. F. (2017). A longitudinal four-dimensional computed tomography and cone beam computed tomography dataset for image-guided radiation therapy research in lung cancer. In Medical Physics (Vol. 44, Issue 2, pp. 762–771). Wiley. https://doi.org/10.1002/mp.12059
Publication Citation
Balik, S., Weiss, E., Jan, N., Roman, N., Sleeman, W. C., Fatyga, M., Christensen, G. E., Zhang, C., Murphy, M. J., Lu, J., Keall, P., Williamson, J. F., & Hugo, G. D. (2013). Evaluation of 4-dimensional Computed Tomography to 4-dimensional Cone-Beam Computed Tomography Deformable Image Registration for Lung Cancer Adaptive Radiation Therapy. In International Journal of Radiation Oncology*Biology*Physics (Vol. 86, Issue 2, pp. 372–379). Elsevier BV. PMCID: PMC3647023. https://doi.org/10.1016/j.ijrobp.2012.12.023
Publication Citation
Roman, N. O., Shepherd, W., Mukhopadhyay, N., Hugo, G. D., & Weiss, E. (2012). Interfractional Positional Variability of Fiducial Markers and Primary Tumors in Locally Advanced Non-Small-Cell Lung Cancer During Audiovisual Biofeedback Radiotherapy. In International Journal of Radiation Oncology*Biology*Physics (Vol. 83, Issue 5, pp. 1566–1572). Elsevier BV. https://doi.org/10.1016/j.ijrobp.2011.10.051
TCIA Citation
Clark K, Vendt B, Smith K, Freymann J, Kirby J, Koppel P, Moore S, Phillips S, Maffitt D, Pringle M, Tarbox L, Prior F. The Cancer Imaging Archive (TCIA): Maintaining and Operating a Public Information Repository, Journal of Digital Imaging, Volume 26, Number 6, December, 2013, pp 1045-1057. DOI: 10.1007/s10278-013-9622-7
Other Publications Using This Data
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Version 2 (Current): Updated 2016/10/19
Any download of this dataset prior to October 18 2016 contains data that was updated after that date by the investigators. It is recommended that you download a fresh copy before applying your analysis.
| Data Type | Download all or Query/Filter |
|---|---|
| Images (DICOM, 183GB) | (Download requires the NBIA Data Retriever .) |
Version 1 : 2015/09/14
| Data Type | Download all or Query/Filter |
|---|---|
| Images (DICOM, 183GB) | (Download requires the NBIA Data Retriever .) |