This collection consists of magnetic resonance images (MRI) of genetically engineered mouse models (GEMMs) of high grade astrocytoma, including glioblastoma multiforme (GBM).
In these GEMMs, the most commonly disregulated networks in GBM -- RB, KRAS and/or PI3K signaling -- are perturbed at the genetic level. These genetic aberrations induce development of high grade astrocytoma in the mouse with properties similar to that of human disease. MRI was used to perform a qualitative and quantitative phenotypic characterization of the different genotypes and molecular subtypes. Additionally, mouse MRI images were compared human GBM imaging parameters using the VASARI lexicon. The MRI data contained herein includes anatomic T2 weighted images and dynamic contrast enhanced MRI.
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Please be sure to include the following citations in your work if you use this data set:
Jansen, Sunny, & Van Dyke, Terry. (2015). TCIA Mouse-Astrocytoma Collection. The Cancer Imaging Archive.http://doi.org/
Clark K, Vendt B, Smith K, Freymann J, Kirby J, Koppel P, Moore S, Phillips S, Maffitt D, Pringle M, Tarbox L, Prior F. The Cancer Imaging Archive (TCIA): Maintaining and Operating a Public Information Repository, Journal of Digital Imaging, Volume 26, Number 6, December, 2013, pp 1045-1057. (paper)
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