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The Cancer Imaging Archive supports a research community that seeks to connect cancer phenotypes to genotypes. To accomplish this, TCIA hosts data sets that connect clinical images with patient genotype data and proteomic data.

In 2006, the National Cancer Institute (NCI) supported a three-year pilot project with The Cancer Genome Atlas (TCGA) and the National Human Genome Research Institute (NHGRI). The focus of the pilot was to construct an atlas of genomic information for different cancer types (initially focused on glioblastoma, ovary, and lung cancers). This effort also demonstrated that national networks can effectively work together to pool their data and develop an infrastructure for making the data publicly available, enabling researchers around the world to make novel discoveries. The success of the pilot encouraged the National Institutes of Health (NIH) to further invest in TCGA efforts and move forward to collect and characterize more than 20 additional tumor types and make the data freely accessible for researchers to download via the TCGA data portal. To further increase the value of this data, the NCI Cancer Imaging Program (CIP) worked with TCGA Tissue Site Source institutions to collect clinical diagnostic images for TCIA that match the genomic data, available for public download.

The following data sets have genomic data to match the clinical imaging data in TCIA:

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The National Cancer Institute’s Clinical Proteomic Tumor Analysis Consortium (CPTAC) is a national effort to accelerate the understanding of the molecular basis of cancer through the application of large-scale proteome and genome analysis, or proteogenomics. Data (genomics, proteomics, imaging), assays, and reagents are made available to the public as a Community Resource to accelerate cancer research and advance patient care. CPTAC has been conducted in multiple phases.  For their phase 3 prospective data collection activities TCIA has partnered with CPTAC to host both the radiology and pathology imaging data generated by the project. The other data types will be hosted in separate databases managed by the CPTAC program. TCIA will provide links to these resources as they become publicly available.

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