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Summary

The TCGA-LUAD Phenotype Research Group is part of the CIP TCGA Radiology Initiative focused on analyzing images from the TCGA-LUAD collections. Multiple modalities of images which correlate to the lung tissue data in the TCGA Data Portal are continuing to be gathered for submission to TCIA.

According to the TCGA page on lung adenocarcinoma, researchers hope to make the following types of discoveries about lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC):

  • Pinpoint gene changes that divide squamous and adenocarcinoma tumors into molecular subgroups
  • Distinguish patterns of gene changes between adenocarcinoma and squamous cell carcinoma
  • Distinguish genomic changes between smokers and non-smokers

Research and Publications

Per TCGA and TCIA Guidelines formal permission requests are still required to submit publications using TCGA-LUAD data.  Please see the following links for more information about the freedom-to-publish criteria for these data sets:

Data Source

Status

TCGA Data Portal Publication Guidelines

Publication limitations in place until 5/30/2013

TCIA Data Usage Policies and Restrictions

Projects have not reached 100 imaging cases; Please check with cancerimagingarchive@mail.nih.gov prior to any publication

Please contact us at cancerimagingarchive@mail.nih.gov if you have any questions about these policies, or would like to join our public mailing list and be kept in the loop about new data releases and other related news as this effort moves forward.

TCGA-LUAD Marker Paper and Image Source Sites (ISS)

Imaging Source Site (ISS) Groups will be populated and governed by participants from institutions that have provided imaging data to the archive for a given cancer type. Modeled after TCGA analysis groups, these groups are given the opportunity to publish a marker paper for a given cancer type per the aforementioned publication policy. It is hoped that this will generate increased participation in the building of these multi-institutional data sets that become an open community resource.  Current TCGA-LUAD source sites include:

  • Washington University in St. Louis

This group has not yet been established.  We will provide a point of contact for the group from the ISS site(s) as soon as possible to address scientific questions or requests to collaborate with their group.

References

The following links contain publications from the main TCGA project, as well as their posted publication guidelines.

TCGA 2nd Annual Symposium

  • Comprehensive Analysis of Lung Adenocarcinoma, Matthew Meyerson, MD, Dana-Farber Cancer Institute.  Video | Slides
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