Summary
The imaging characteristics of this model (PDMR-997537-175-T), which is available from the National Cancer Institute Patient-Derived Models Repository (https://pdmr.cancer.gov/), is highly favorable for preclinical research studies of metastatic disease when used in conjunction with non-contrast T2 weighted MRI.
Results: Adenocarcinoma colon (PDMR-997537-175-T)
Table 1: Penetrance and location of pathological confirmed metastatic lesion(s).
# animals in group | # animals that displayed metastasis in MRI and confirmed by Pathology | Pathology confirmation of MRI (primary imaging site) | Other confirmed Location (s) | Mouse ID: MRI with pathology confirmation of metastasis |
10 (non-resected) | 6 (4 mice were EU due to xenograft size prior to observation of metastasis) | Lung | Lymph Node | 1319, 1321, 1326, 1327, 1334, 1338 |
10 (resected) | 10 | Lung | Lymph Node | 1320, 1323, 1324, 1325, 1328, 1329, 1332, 1333, 1335, 1337 |
Percent penetrance with respect to the average time-to-metastasis for non-resected (plot A: time from implant) and resected (plot B: time from tumor resection) cohorts.
Plot A | Plot B |
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PET/CT Characterization of the primary tumor: Baseline PET (SOP attached) were performed when tumor reached an approximate 200 mm3. Average SUVmax values (n=5) were calculated; [18F]FDG: 4.4 ± 0.6 and [18F]FLT: 1.3 ± 0.3.
Conclusion:
Excellent metastatic model with at least 60% penetrance non-resected and 100% with planned resection. Metastases well observed on T2 MRI imaging allowing non-invasive evaluation in treatment trials. This model can be challenging in a drug study due to the rapid xenograft tumor growth and re-growth after tumor excision.
Acknowledgements
We would like to acknowledge the individuals and institutions that have provided data for this collection:
- Frederick National Laboratory for Cancer Research – Special Thanks to Joseph D. Kalen, PhD, Lilia V. Ileva, MS, Lisa A Riffle, Nimit Patel, Keita Saito, PhD, Yvonne Evrard, PhD, Elijah Edmondson, DVM, PhD, Jessica Phillips, Simone Difilippantonio, PhD, Chelsea Sanders, Amy James, Lia Thang, Ulrike Wagner, Yanling Liu, PhD, John B. Freymann, and Justin Kirby
- Division of Cancer Therapeutics and Diagnosis/National Cancer Institute - James L. Tatum, MD, Paula M Jacobs, PhD, Melinda G. Hollingshead, DVM, and James H. Doroshow, MD
- PixelMed Publishing – Special Thanks to David A. Clunie, MD
- University of Arkansas for Medical Sciences – Special Thanks to Kirk E. Smith
- This project has been funded in whole or in part with Federal funds from the National Cancer Institute, National Institutes of Health, under Contract No. HHSN261201500003I. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government.
Data Access
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Data Type | Download all or Query/Filter |
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Images (DICOM, 2.3 GB) | (Download requires NBIA Data Retriever) |
PDMR Patient Specimen (external) | |
Standard Operating Procedure 50101 MRI T2 Weighted Non-Contrast Protocol Single Mouse Pulmonary Gated and Multi-Mouse Non-Gated | |
Standard Operating Procedure 50102 Positron Emission Tomography (PET) imaging protocol |
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Detailed Description
Image Statistics |
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Modalities | MR, SR |
Number of Subjects | 24 |
Number of Studies | 76 |
Number of Series | 128 |
Number of Images | 1966 |
Images Size (GB) | 1.2 GB |
Citations & Data Usage Policy
Data Citation
Tatum, J. L., Kalen, J. D., Ileva, L. V., Riffle, L. A., Keita, S., Patel, N., Jacobs, P. M., Sanders, C., James, A., Difilippantonio, S., Thang, L., Hollingshead, M. G., Phillips, J., Evrard, Y., Clunie, D. A., Liu, Y., Suloway, C., Smith, K. E., Wagner, U., … Doroshow, J. H. (2020). Imaging characterization of a metastatic patient derived model of adenocarcinoma colon: PDMR-997537-175-T [Data set]. The Cancer Imaging Archive. https://doi.org/10.7937/TCIA.2020.BRY9-4N29
Acknowledgement
This project has been funded in whole or in part with Federal funds from the National Cancer Institute, National Institutes of Health, under Contract No. HHSN261201500003I. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government.
TCIA Citation
Clark K, Vendt B, Smith K, Freymann J, Kirby J, Koppel P, Moore S, Phillips S, Maffitt D, Pringle M, Tarbox L, Prior F. The Cancer Imaging Archive (TCIA): Maintaining and Operating a Public Information Repository, Journal of Digital Imaging, Volume 26, Number 6, December, 2013, pp 1045-1057. DOI: https://doi.org/10.1007/s10278-013-9622-7
Other Publications Using This Data
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Version 1 (Current): Updated 2020/05/22
Data Type | Download all or Query/Filter |
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Images (DICOM, 2.3 GB) | (Requires NBIA Data Retriever .) |
PDMR Patient Specimen (external) | |
Standard Operating Procedure 50101 MRI T2 Weighted Non-Contrast Protocol Single Mouse Pulmonary Gated and Multi-Mouse Non-Gated | |
Standard Operating Procedure 50102 Positron Emission Tomography (PET) imaging protocol |