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  • Glioma Image Segmentation for Radiotherapy: RT targets, barriers to cancer spread, and organs at risk (GLIS-RT)


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This collection consists of 230 cases of glioblastoma and low-grade glioma patients treated with surgery and adjuvant radiotherapy at Massachusetts General Hospital. The patients underwent routine post-surgical MRI examination by acquiring two MR sequences, contrast enhanced 3D-T1 and 2D multislice-T2 FLAIR required to define target volumes for radiotherapy treatment. CT scans were acquired after diagnostic imaging to use in radiotherapy treatment planning. All cases in the image set are provided with the radiotherapy targets, gross tumor volume (GTV) and clinical target volume (CTV) manually delineated by the treating radiation oncologist. The set includes glioblastoma (GBM) - 198 cases, anaplastic astrocytoma (AAC) - 23 cases, astrocytoma (AC) - 5 cases, anaplastic oligodendroglioma (AODG) - 2 cases, and oligodendroglioma (ODG) - 2 case. These abbreviations are included in the case ID. 

For all cases, manual delineations are provided for the RT targets (GTV and CTV) and for organs at risk,  the brainstem, optic chiasm, optic nerves, eyes, cochleae, and lacrimal glands. A subset of these 230 cases consisting of 75 cases was used for the International Challenge “Anatomical Brain Barriers to Cancer Spread: Segmentation from CT and MR Images”, ABCs, organized in conjunction with the MICCAI 2020 conference ( For these cases, manual delineations are provided for the structures used for automated definition of the CTV: the falx cerebri, tentorium cerebelli, transverse and sagittal brain sinuses, ventricles, cerebellum. 

The images and manually delineated structures are to be used to develop methods for computer assisted radiotherapy target definition, algorithms for auto-delineation of the normal anatomical structures to be used for radiotherapy treatment plan optimization, and methods that utilize multi-modality images for deep learning-based image segmentation.


The project was supported by the Therapy Imaging Program (TIP) funded by the Federal Share of program income earned by Massachusetts General Hospital on C06 CA059267, Proton Therapy Research and Treatment Center.

Data Access

Some data in this collection contains images that could potentially be used to reconstruct a human face. To safeguard the privacy of participants, users must sign and submit a TCIA Restricted License Agreement to before accessing the data.

Data TypeDownload all or Query/FilterLicense

Images, Image Registrations, and Radiation Therapy Structures (DICOM, 28.3 GB)


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Detailed Description

Image Statistics



Number of Patients


Number of Studies


Number of Series


Number of Images


Images Size (GB)28.3

Citations & Data Usage Policy

Users must abide by the TCIA Data Usage Policy and Restrictions. Attribution should include references to the following citations:

Data Citation

Shusharina, N., & Bortfeld, T. (2021). Glioma Image Segmentation for Radiotherapy: RT targets, barriers to cancer spread, and organs at risk (GLIS-RT) [Data set]. The Cancer Imaging Archive.

Publication Citation

Shusharina N., Bortfeld T., Cardenas C., De B., Diao K., Hernandez S., Liu Y., Maroongroge S., Söderberg J., Soliman M. Cross-Modality Brain Structures Image Segmentation for the Radiotherapy Target Definition and Plan Optimization. Segmentation, Classification, and Registration of Multi-modality Medical Imaging Data: MICCAI 2020 Challenges, ABCs 2020, L2R 2020, TN-SCUI 2020, Held in Conjunction with MICCAI 2020, Lima, Peru, October 4–8, 2020, Proceedings, 12587, 3–15. 

TCIA Citation

Clark K, Vendt B, Smith K, Freymann J, Kirby J, Koppel P, Moore S, Phillips S, Maffitt D, Pringle M, Tarbox L, Prior F. The Cancer Imaging Archive (TCIA): Maintaining and Operating a Public Information Repository, Journal of Digital Imaging, Volume 26, Number 6, December, 2013, pp 1045-1057. DOI: 10.1007/s10278-013-9622-7

Other Publications Using This Data

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Version 1 (Current): 2021/12/20

Data TypeDownload all or Query/Filter
Images, Image Registrations, and Radiation Therapy Structures (DICOM, 28.3 GB)
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