Summary

According to The Cancer Genome Atlas TCGA’s page on invasive breast cancers, researchers have:

• Described new integrated insights into the four standard molecular subtypes of breast cancer: HER2-enriched, Luminal luminal A, Luminal luminal B, and Basalbasal-like.

• Also, identified Identified mutated genes that are specific to each subtype.

• Found that the Basalbasal-like subtype shares many genetic features with high-grade serous ovarian cancer, suggesting that the these cancers have a common molecular origin and may share therapeutic opportunities.
• Performed computational analyses suggesting that suggest that Basalbasal-like breast cancer and serous ovarian cancer might both be susceptible to two types of cancer treatmentA drug that inhibits :
• Anti-angiogenesis drugs that inhibit blood vessel growth, cutting off
the
• blood supply to the tumor;
• Bioreductive drugs, which are normally inactive
drugs that
• but become toxic to cancer cells under low oxygen conditions

Research and Publications

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TCGA Breast Marker Paper and Image Source Sites (ISS)

Imaging Source Site (ISS) Groups groups will be populated and governed by participants from institutions that have provided imaging data to the archive for a given cancer type. Modeled after TCGA analysis groups, these ISS groups are given the opportunity to publish a marker paper for a given cancer type per the aforementioned publication policy. It is hoped that this per TCGA Publication Guidelines. This opportunity will generate increased participation in the building of these multi-institutional data sets that as they become an open community resource.   Current TCGA-BRCA source sites include:

• Mayo Clinic
• Roswell Park Cancer Institute
• Memorial Sloan-Kettering Cancer Center
• MemorialSloan-KetteringCancerCenter
• Universityof University of Pittsburgh/UPMC

Please contact Dr. Elizabeth Morris (morrise@mskcc.org) if you have scientific questions you would like to direct to the for TCGA-BRCA ISS or are interested in collaborating with their group.

Research and Publications

Please contact us at cancerimagingarchive@mail.nih.gov if you have any questions about these policies.

References

Conference abstracts utilizing TCGA-Breast imaging data from TCIA:

•  ARRS 2014
•  TCGA Symposium 2014

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The following links contain publications from the main TCGA project, as well as their posted publication guidelines.

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