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The TCGA Breast Phenotype Research Group is part of the CIP TCGA Radiology Initiative focused on analyzing images from the TCGA-BRCA collection. These images correlate to the Breast Invasive Carcinoma (BRCA) data in the TCGA Data Portal. |
According to The Cancer Genome Atlas page on invasive breast cancers researchers have:
- Described new integrated insights into the four standard molecular subtypes of breast cancer: HER2-enriched, Luminal A, Luminal B, and Basal-like
- Also, identified mutated genes that are specific to each subtype
- Found that the Basal-like subtype shares many genetic features with high-grade serous ovarian cancer suggesting that the cancers have a common molecular origin and may share therapeutic opportunities
- Performed computational analyses that suggest that Basal-like breast cancer and serous ovarian cancer might both be susceptible to two types of cancer treatment
- A drug that inhibits blood vessel growth, cutting off the blood supply to the tumor
- Bioreductive drugs, which are inactive drugs that become toxic to cancer cells under low oxygen conditions
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