The TCGA-GBM data collection is part of a larger effort to enhance the The Cancer Genome Atlas (TCGA) data set with characterized radiological images. The Cancer Imaging Program (CIP) with the cooperation of several of the TCGA tissue-contributing institutions has archived a large portion of the radiological images of the genetically-analyzed GBM cases.Clinical, genetic, and pathology data reside in the TCGA data portal while the radiological data is stored on The Cancer Imaging Archive (TCIA). The data utilizes the same TCGA patient identifiers in both repositories, allowing researchers to explore the correlations between tissue genotype and radiological phenotype. This Collection within TCIA is related to the GBM disease type within TCGA.
TCIA and TCGA Subject Identifiers and Dates
Subject Identifiers: a subject with radiology images stored in The Cancer Imaging Archive (TCIA) is identified with a Patient ID that is identical to the Patient ID of the same subject with demographic, clinical, pathological, and/or genomic data stored in the Cancer Genome Atlas (TCGA). For each TCGA case, the baseline TCGA imaging studies found on TCIA are pre-surgical.
Dates: TCIA and TCGA handle dates differently, and there are no immediate plans to reconcile:
- TCIA Dates: dates (be they birthdates, imaging study dates, etc.) in the DICOM headers of TCIA radiology images have been offset by a random number of days. The offset is a number of days between 3 and 10 years prior to the real date that is consistent for each TCIA image-submitting site and collection but that varies among sites and among collections from the same site. Thus, the number of days between a subject’s longitudinal imaging studies are accurately preserved when more than one study has been archived while still meeting HIPAA requirements.
- TCGA Dates: the patient demographic and clinical event dates are all the number of days from the index date, which is the actual date of pathologic Dx. So all the dates in the data are relative negative or positive integers, except for the “days_to_pathologic_diagnosis” value, which is 0 – the index date. The years of birth and Dx are maintained in the distributed clinical data file. The NCI retains a copy of the data with complete dates, but those data are not made available.With regard to other TCGA dates, if a date comes from a HIPAA “covered entity’s” medical record, it is turned into the relative day count from the index date. Dates like the date TCGA received the specimen or when the TCGA case report form was filled out are not such covered dates, and they will appear as real dates (month, day, year).
We would like to acknowledge the individuals and institutions that have provided data for this collection:
- Henry Ford Hospital, Detroit, MI - Special thanks to Lisa Scarpace and Tom Mikkelsen, MD from the Department of Neurosurgery, Hermelin Brain Tumor Center.
- University of California, San Francisco, CA - Special thanks to Soonmee Cha, MD from the Department of Neurological Surgery, Brain Tumor Research Center.
- MD Anderson Cancer Center, Houston, TX - Special thanks to Sujaya Rao and Sangeeta Tekchandani from the Office of Translational/Clinical Research.
- Emory University, Atlanta, GA - Special thanks to David Gutman, MD, PhD and Joel Saltz, MD, PhD from the Center for Comprehensive Informatics.
- Mayo Clinic, Rochester, MN - Special thanks to Bradley J. Erickson, MD, PhD from the Department of Radiology, Mayo Medical School.
- Thomas Jefferson University, Philadelpha, PA - Special thanks to Nancy Pedano and Adam E. Flanders, MD from the Department of Radiology, Jefferson Medical College.
- CWRU School of Medicine, Cleveland, OH - Special thanks to Jill Barnholtz-Sloan, PhD and Quinn Ostrom, MA, MPH from Case Comprehensive Cancer Center.
- Duke University School of Medicine, Durham, NC - Special thanks to Daniel Barboriak, MD and Laura J Pierce.
CIP TCGA Radiology Initiative
The Cancer Imaging Program is supporting multiple projects within the academic community to encourage cross disciplinary research which utilizes the data provided in these resources. Much more can be learned about this effort on the TCGA Glioma Phenotype Research Group page.
Number of Patients
Number of Studies
Number of Series
Number of Images
If you are unsure how to download this Collection please view our quick guide on Searching by Collection or refer to our The Cancer Imaging Archive User's Guide for more detailed instructions on using the site.
The TCGA data portal has extensive clinical and genomic data which can be matched to the patient identifiers of the images here in TCIA. Here is a snapshot of the data obtained from the data portal on 2/6/2014:
Verbose explanations of the clinical data can be found on the Biospecimen Core Resource Clinical Data Forms linked below: