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Summary

The TCGA-GBM data collection is part of a larger effort to enhance the The Cancer Genome Atlas (TCGA) data set with characterized radiological images.  The Cancer Imaging Program (CIP) with the cooperation of several of the TCGA tissue-contributing institutions has archived a large portion of the radiological images of the genetically-analyzed GBM cases.

Clinical, genetic, and pathology data resides in the TCGA data portal while the radiological data is stored on The Cancer Imaging Archive (TCIA).   The data utilizes the same TCGA patient identifiers in both repositories, allowing researchers to explore the correlations between tissue genotype and radiological phenotype. This Collection within TCIA is related to the GBM disease type within TCGA.

We would like to acknowledge the individuals and institutions that have provided data for this collection:

  • Henry Ford Hospital, Detroit, MI - Special thanks to Lisa Scarpace and Tom Mikkelsen, MD from the Department of Neurosurgery, Hermelin Brain Tumor Center.
  • University of California, San Francisco, CA - Special thanks to Soonmee Cha, MD from the Department of Neurological Surgery, Brain Tumor Research Center.
  • MD Anderson Cancer Center, Houston, TX - Special thanks to Sujaya Rao and Sangeeta Tekchandani from the Office of Translational/Clinical Research.
  • Emory University, Atlanta, GA - Special thanks to David Gutman, MD, PhD and Joel Saltz, MD, PhD from the Center for Comprehensive Informatics.
  • Mayo Clinic, Rochester, MN - Special thanks to Bradley J. Erickson, MD, PhD from the Department of Radiology, Mayo Medical School.
  • Thomas Jefferson University, Philadelpha, PA - Special thanks to Adam E. Flanders, MD and Nancy Pedano from the Department of Radiology, Jefferson Medical College. (Submission in progress)

Metadata

Here is just a sample of some of the corresponding clinical data available in the TCGA data portal which can be matched to the patient identifiers of the images here in TCIA:

bcr_patient_barcode,additional_chemo_therapy,additional_drug_therapy,additional_hormone_therapy,additional_immuno_therapy,additional_pharmaceutical_therapy,additional_radiation_therapy,age_at_initial_pathologic_diagnosis,
anatomic_organ_subdivision,chemo_therapy,days_to_birth,days_to_death,days_to_initial_pathologic_diagnosis,days_to_last_followup,days_to_tumor_progression,days_to_tumor_recurrence,drugs,gender,histological_type,hormonal_therapy,
immuno_therapy,informed_consent_verified,initial_pathologic_diagnosis_method,person_neoplasm_cancer_status,pretreatment_history,prior_glioma,radiation_therapy,radiations,targeted_molecular_therapy,tumor_tissue_site,vital_status,
year_of_initial_pathologic_diagnosis

Data Access

Collection Statistics

(updated 5/15/2012)

Modalities

MR

Number of Patients

194

Number of Studies

863

Number of Series

7,951

Number of Images

603,425

You can view and download these images on the Cancer Imaging Archive by selecting the TCGA-GBM collection. If you are unsure how to download this Collection view our quick guide on Searching by Collection or you can refer to our The Cancer Imaging Archive User's Guide for more detailed instructions on using the site.

CIP TCGA Radiology Initiative

The Cancer Imaging Program has begun multiple projects to collaborate with the academic community to encourage cross disciplinary research which utilizes the data provided in these resources.  Much more can be learned about this effort on the TCGA Glioma Phenotype Research Group page.

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