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  • The Cancer Genome Atlas Low Grade Glioma Collection (TCGA-LGG)

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Summary

The TCGA-LGG data collection is part of a larger effort to enhance the The Cancer Genome Atlas (TCGA) data set with characterized radiological images.  The Cancer Imaging Program (CIP) with the cooperation of several of the TCGA tissue-contributing institutions has archived a large portion of the radiological images of the genetically-analyzed low grade glioma (LGG) cases.

Clinical, genetic, and pathology data resides in the TCGA data portal while the radiological data is stored on The Cancer Imaging Archive (TCIA).   The data utilizes the same TCGA patient identifiers in both repositories, allowing researchers to explore the correlations between tissue genotype and radiological phenotype. This Collection within TCIA is related to the LGG disease type within TCGA.

We would like to acknowledge the individuals and institutions that have provided data for this collection:

  • Thomas Jefferson University, Philadelpha, PA - Special thanks to Nancy Pedano and Adam E. Flanders, MD from the Department of Radiology, Jefferson Medical College.
  • Henry Ford Hospital, Detroit, MI - Special thanks to Lisa Scarpace and Tom Mikkelsen, MD from the Department of Neurosurgery, Hermelin Brain Tumor Center. (in progress)

Metadata

The TCGA data portal has extensive clinical and genomic data which can be matched to the patient identifiers of the images here in TCIA.  Here are just a sample of some of the clinical data types available:

bcr_patient_barcode,additional_chemo_therapy,additional_drug_therapy,additional_hormone_therapy,additional_immuno_therapy,additional_pharmaceutical_therapy,additional_radiation_therapy,age_at_initial_pathologic_diagnosis,
anatomic_organ_subdivision,chemo_therapy,days_to_birth,days_to_death,days_to_initial_pathologic_diagnosis,days_to_last_followup,days_to_tumor_progression,days_to_tumor_recurrence,drugs,gender,histological_type,hormonal_therapy,
immuno_therapy,informed_consent_verified,initial_pathologic_diagnosis_method,person_neoplasm_cancer_status,pretreatment_history,prior_glioma,radiation_therapy,radiations,targeted_molecular_therapy,tumor_tissue_site,vital_status,
year_of_initial_pathologic_diagnosis

Data Access

Collection Statistics

(updated 7/25/2012)

Modalities

MR

Number of Patients

26

Number of Studies

28

Number of Series

463

Number of Images

15,411

You can view and download these images on the Cancer Imaging Archive by selecting the TCGA-GBM collection. If you are unsure how to download this Collection view our quick guide on Searching by Collection or you can refer to our The Cancer Imaging Archive User's Guide for more detailed instructions on using the site.

CIP TCGA Radiology Initiative

The Cancer Imaging Program is supporting multiple projects within the academic community to encourage cross disciplinary research which utilizes the data provided in these resources.  Much more can be learned about this effort on the TCGA Glioma Phenotype Research Group page.

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