Pilot Phase
A pilot project was performed in 2010 centered around the development of informatics tools to analyze the radiological data in combination with the the existing clinical, genetic, and pathological data in the TCGA Data Portal. CIP worked with both Henry Ford and UCSF to collect and de-identify the DICOM data for a subset of the GBM patients and load this data into the NCI Center for Bioinformatics and Information Technology (CBIIT) instance of the National Biomedical Imaging Archive. In parallel NCI's caBIG program funded the extension of 3 existing DICOM workstations to support standardized markup and characterization of these images utilizing the Annotated Imaging and Markup (AIM) XML standard. This effort has since led to a number of projects attempting to analyze this data.
Expanding the scope of TCGA Radiology
Continuing these efforts CIP is working to accrue images from additional sites for both GBM and the other tissue types being collected as part of the original TCGA project. Please see the child pages below to view ongoing projects and data availability for each cancer type. Efforts have already begun in the following TCGA tissue types:
- GBM - Glioblastoma multiforme
- BRCA - Breast invasive carcinoma (coming soon)
Driven by input from its scientific community, the Cancer Imaging Program (CIP) finds itself at the junction of two powerful scientific requisites; the need for cross-disciplinary research and inter-institutional data-sharing to speed scientific discovery and reduce redundancy, and the need to provide imaging phenotype data to augment large scale genomic analysis.
...
Presently, CIP is developing material transfer agreements with many of the TCGA Tissue Site Source institutions to recover and place in the Image Archive collections of diagnostic images that match the genomic data now being deposited in the publically accessible TCGA Data Portal on cancers of the breast (BRCA) renal (KIRC) and lung (LUAD) and in due time, many of the future 20-plus tumors that TCGA will characterize as the program moves forward.
Continuing these efforts CIP is working to accrue images from additional sites for both GBM and the other tissue types being collected as part of the original TCGA project. Please see the child pages below to view ongoing projects and data availability for each cancer type. Efforts have already begun in the following TCGA tissue types:
- GBM - Glioblastoma multiforme
- BRCA - Breast invasive carcinoma (coming soon)