The TCGA Glioma Phenotype Research Group is part of the CIP TCGA Radiology Initiative focused on analyzing images from the TCGA-GBM and TCGA-LGG collections. The group began as an ad hoc multi-institutional research team dedicated to discovering the value of applying controlled terminology to the MR imaging features of patients with gliomas (see: VASARI Research Project).  Research trials that incorporate imaging present unique challenges due to nonstandard use of terminologies, absence of uniform data collection and validation. These obstacles traditionally limit the impact of imaging as an effective biomarker in oncology. The original purpose of this project was to assess reliability of tools and terminology developed by the Cancer Bioinformatics Grid (caBIG) initiative when performing a multireader simultaneous assessments of glioblastoma MR imaging features.  It has since grown into a number of diverse research initiatives conducted by a geographically disparate open science research teamteams.