Summary

As part of the Cancer Imaging Program (CIP) mission to link archived images from the Cancer Imaging Archive (TCIA) with phenotype research performed under the auspices of the Cancer Genome Atlas (TCGA), glioma tissue data and images have been correlated.

The TCGA Glioma Phenotype Research Group is part of the the CIP TCGA Radiology Initiative focused  focused on analyzing images from the the TCGA-Glioblastoma Multiforme (GBM and ) and TCGA-LGG collectionsLower Grade Glioma (LGG) collections. Images which correlate correlating to the Glioblastoma Multiforme and Lower Grade Glioma GBM and LGG tissue data in the the TCGA Data Portal are continuing   continue to be gathered for submission to to TCIA.

According to the the TCGA page on Glioblastoma MultiformeGBM, researchers have already made the following types of discoveries with this data:

• Identified a new subtype of GBM that affects younger adults and has an increased survival rate. A subset of GBM tumors had large groups of genes with specific chemical changes or 'marks' called methylation of a large group of genes. The methylation of these genes may account for the improved survival of in these patients when compared to patients with other subtypes of GBM. These findings could aid in development of new treatment options for these patients.
• Recognized four distinct molecular subtypes of GBM that respond differently to aggressive therapies. Patients with one subtype survive about 50 percent longer than those with other GBM subtypes. Knowing a tumor's subtype could help match each patient to the most effective therapiestherapy. See more information about TCGA brain tumor subtype studies.
• Identified possible mechanisms that can cause some GBM tumors to become resistant to therapy after treatment with the standard chemotherapy called temozolomide. Treatment with temozolomide , temozolomide, which can cause gene mutations that help tumor cells become resistantleading to tumor resistance. If GBM tumors return after successful treatment with temozolomide, the new gene mutations make the tumor resistant to further drug treatment with the drug. This finding could be used to develop new drugs that will not activate this drug resistance mechanism.
• Pinpointed four gene mutations in GBM tumors that may provide new insights into the biology of this disease.
  • NF1, a gene identified as the cause of neurofibromatosis 1, a rare, inherited disorder characterized by uncontrolled tissue growth along nerves.
  • ERBB2, a gene involved in breast cancer.
  • TP53, a gene involved in many types of cancers.
  • PIK3R1, a gene that controls an enzyme
that is
• • found in many cancers.

Per the the TCGA page on Lower Grade GliomaLGG, researchers also hope to make the following types of discoveries:

• Define the gene expression patterns of adult lower grade gliomas as compared to LGGs compared with pediatric cases that have been studied in other programs.
• Determine if there are genomic changes that correlate with malignancy.
• Examine genetic changes that emerge when lower grade glioma becomes to glioblastoma multiformeLGG becomes GBM.
• Identify clinical features that are associated with a specific pattern of genomic changes.

Research and Publications

...

Please contact us at cancerimagingarchive@mail.nih.gov if you have any questions about these policies.

...

Imaging Source Site (ISS) Groups groups are populated and governed by participants from institutions that have provided providing imaging data to the archive for a given cancer type. Modeled after TCGA analysis groups, these groups are given have the opportunity to publish a marker paper for a given cancer type per the aforementioned publication policy. The TCGA Glioma Phenotype Research Group's formation pre-dated current TCIA policies on TCGA related publications and therefore ; thus,there is no ISS marker paper for TCGA-GBM imaging data. However, several publications and numerous conference presentations utilizing this data have been generated by the research group, which are groups outlined below in the References references section. Analysis of TCGA-LGG imaging data is currently underway.  Current  Current TCGA-GBM and TCGA-LGG source sites include:

• ThomasJeffersonUniversity
• HenryFordHospital
• UniversityofCalifornia
• Thomas Jefferson University
• Henry Ford Hospital
• University of California,San Francisco
• MD Anderson Cancer Center
• MDAndersonCancerCenter
• EmoryUniversityEmory University
• Mayo Clinic
• CWRU School of CWRUSchoolof Medicine

Please contact contact cancerimagingarchive@mail.nih.gov if you have scientific questions you would like to direct to the for TCGA-GBM/LGG ISS or if you are interested in collaborating with their group.

...

Note: For more information on how Shared Lists shared lists are used to cite and share data please view our TCIA Citation Guidelines.

...