Driven by input from
the scientific community, the Cancer Imaging Program (CIP)
stands at the
crossroad of two powerful scientific requisites
: the need for cross-disciplinary research and the increase of inter-institutional data
. The Cancer Imaging Archive (TCIA) is building a research community focused on connecting cancer phenotypes to genotypes by
providing clinical images matched to
subjects from The Cancer Genome Atlas (TCGA).
TCGA began in 2006 as a three-year pilot jointly sponsored by the National Cancer Institute (NCI) and National Human Genome Research Institute (NHGRI). The TCGA pilot project (focused initially on glioblastoma, ovary, and lung cancers) confirmed that an atlas of genomic changes could be constructed for specific cancer types. It also showed that a national network networks of research and technology teams working on related projects could pool their efforts, create an economy of scale, and develop an infrastructure for making the data publicly accessible. Importantly, it proved that making the data freely available would enable distributed researchers Freely available data enables researchers across the world to make and validate important discoveries. The success of that pilot led encouraged the National Institutes of Health to commit major new resources to TCGA to (NIH) to invest in TCGA’s efforts to collect and characterize more than 20 additional tumor types and make findings freely accessible for researchers to download via TCGA Data Portal.
As an opportunity to leverage that this wealth of new biomedical knowledge, CIP committed substantial effort to gather and place in The Cancer Imaging Archive the used its agreements with TCGA Tissue Site Source institutions to collect clinical diagnostic images for TCIA that match the genomically analyzed TCGA tissue cases . CIP has encouraged an ad hoc image research team to study glioblastoma. The Cancer Imaging Archive now contains a TCGA GBM collection with images from more than 150 cases whose molecular and clinical patient data can be accessed in the TCGA Data Portal. A multi-institutional team coordinated by Dr Adam Flanders of Thomas Jefferson University assembled researchers from University of Virginia, Emory, Stanford, Henry Ford Hospital and NCI CCR have created the TCGA Glioma Phenotype Research Group. In less than a year's time they have quickly demonstrated the advantages of such scientific collaboration by their rapid scientific progress with a number of publications and abstracts presented and in the pipeline for future venues.
Presently, CIP is developing agreements with many of the TCGA Tissue Site Source institutions to recover and place in the Image Archive collections of diagnostic images that match the genomic data now being deposited in the publically accessible TCGA Data Portal on cancers of the breast (BRCA) renal (KIRC) and lung (LUAD) and in due time, many of the future 20-plus tumors that TCGA will characterize as the program moves forward.
Continuing these efforts CIP is working to accrue images from additional sites for both GBM and the other tissue types being collected as part of the original TCGA project. Please see the child pages below to view ongoing projects and data availability for each cancer type. Efforts have already begun in the following TCGA tissue types:
- GBM - Glioblastoma multiforme (GBM) data is actively being analyzed by the TCGA Glioma Phenotype Research Group
- BRCA - Breast invasive carcinoma (BRCA) data is currently in the training stages of analysis by the TCGA Breast Phenotype Research Group while waiting for the TCGA-BRCA collection to be loaded to TCIA.
- KIRC - Kidney renal clear cell carcinoma (KIRC) data is in the early stages of data collection and formation of the TCGA Renal Phenotype Research Group.
in the 20-plus cancer types that TCGA has characterized.
Ongoing Research Efforts
Imaging Source Site (ISS) Groups are being populated and governed by participants from institutions that have provided imaging data to the archive for a given cancer type. Modeled after TCGA analysis groups, ISS groups are given the opportunity to publish a marker paper for a given cancer type per the guidelines in the table above. This opportunity will generate increased participation in building these multi-institutional data sets as they become an open community resource. Current ISS groups include:
|TCGA Bladder Phenotype Research Group||Urothelial Bladder Carcinoma (BLCA)|
TCGA Collections Publication Guidelines
TCIA publication guidelines, derived from the policy outlined by TCGA, must be followed in addition to the TCGA Data Portal publication policy: http://cancergenome.nih.gov/abouttcga/policies/publicationguidelines.
There are no limitations on publications containing analyses using TCGA-linked imaging data sets, if the data set meets one of the following three freedom-to-publish criteria:
- A marker paper has been published on that tumor type; or
- It has been 12 months since the authors’ DICOM data for 100 cases of a given tumor type have been published on TCIA; or
- The author receives specific approval from the TCGA ISS groups representing any relevant tumor types.
The following links contain publications from the main TCGA project as well as their posted publication guidelines:
Included below are some posters and presentations which help summarize the CIP TCGA Radiology Initiative and its supporting components such as TCIA.
- TCIA Workshop at 2014 TCGA Symposium - Presented at TCGA Scientific Symposium, May 12, 2014 in Washington, DC.
- Imaging and Genomics: Is There a Synergy? - Published in Radiology 2012 ,264:329–31.
- A Scalable Methodology for Correlating Clinical Imaging Features with TCGA Data - presented Presented at TCGA Network Symposium, November 17-1817–18, 2011 Washington, DC.
- The Cancer Imaging Archive: a Repository of Advanced Imaging Information Correlated with TCGA Samples - presented Presented at TCGA Network Symposium, November 17-1817–18, 2011 Washington, DC.