Driven by input from the scientific community, the Cancer Imaging Program (CIP) stands at the crossroad of two powerful scientific requisites: the need for cross-disciplinary research and the increase of inter-institutional data sharing. The Cancer Imaging Archive (TCIA) is building a research community focused on connecting cancer phenotypes to genotypes by providing clinical images matched to subjects from The Cancer Genome Atlas (TCGA).
began in 2006 as a three-year pilot jointly sponsored by the National Cancer Institute (NCI) and National Human Genome Research Institute (NHGRI). The TCGA pilot project (focused initially on glioblastoma, ovary, and lung cancers) confirmed that an atlas of genomic changes could be constructed for specific cancer types. It also showed that national networks of research and technology teams working on related projects could pool their efforts, create an economy of scale, and develop an infrastructure for making the data publicly accessible.
The success of that pilot encouraged the National Institutes of Health (NIH) to invest in TCGA’s efforts to collect and characterize more than 20 additional tumor types and make findings freely accessible for researchers to download
The genomic, clinical and histopathology images from the project are available via NCI's Genomic Data Commons. NCI's Cancer Imaging Program subsequently leveraged the agreements with TCGA Tissue Site Source institutions Sites to collect clinical diagnostic images for TCIA that match genomically analyzed tissue cases in the 20-plus cancer types that TCGA has characterized.
from these subjects and make them available on TCIA. By combining the imaging data from TCIA with the other data types collected by TCGA a research community focused on connecting cancer phenotypes to genotypes was formed, resulting in over one hundred peer-reviewed publications about these data.
Radiology data for TCGA patients are hosted on TCIA. Pathology images were collected prior to TCIA's involvement in the project, and are hosted on NCI's Genomic Data Commons along with the genomic and clinical data from these studies. Use the links in the table to access each type of imaging data.
|Locations||Modalities||Radiology (Subjects)||Pathology (Subjects)|
|TCGA-BLCA||Bladder Endothelial Carcinoma||Bladder||CT, CR, MR, PT, DX, Pathology||120|
|TCGA-BRCA||Breast Cancer||Breast||MR, MG, Pathology||139||1098|
|TCGA-CESC||Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma||Cervix||MR, Pathology||54||307|
|TCGA-COAD||Colon Adenocarcinoma||Colon||CT, Pathology||25||460|
|TCGA-ESCA||Esophageal Carcinoma||Esophagus||CT, Pathology||16||183|
|TCGA-GBM||Glioblastoma Multiforme||Brain||MR, CT, DX, Pathology||262||606|
|TCGA-HNSC||Head and Neck Squamous Cell Carcinoma||Head-Neck||CT, MR, PT, RTSTRUCT, RTPLAN, RTDOSE, Pathology||227||520|
|TCGA-KICH||Kidney Chromophobe||Kidney||CT, MR, Pathology||15||113|
|TCGA-KIRC||Kidney Renal Clear Cell Carcinoma||Renal||CT, MR, CR, Pathology||267||537|
|TCGA-KIRP||Kidney Renal Papillary Cell Carcinoma||Renal||CT, MR, PT, Pathology||33||288|
|TCGA-LGG||Low Grade Glioma||Brain||MR, CT, Pathology||199||515|
|TCGA-LIHC||Liver Hepatocellular Carcinoma||Liver||MR, CT, PT, Pathology||97||377|
|TCGA-LUAD||Lung Adenocarcinoma||Chest||CT, PT, NM, Pathology||69||514|
|TCGA-LUSC||Lung Squamous Cell Carcinoma||Lung||CT, NM, PT, Pathology||37||495|
|TCGA-OV||Ovarian Serous Cystadenocarcinoma||Ovary||CT, MR, Pathology||143||590|
|TCGA-PRAD||Prostate Cancer||Prostate||CT, PT, MR, Pathology||14||496|
|TCGA-READ||Rectum Adenocarcinoma||Rectum||CT, MR, Pathology||3||171|
|TCGA-SARC||Sarcomas||Chest-Abdomen-Pelvis, Leg, TSpine||CT, MR, Pathology||5||261|
|TCGA-STAD||Stomach Adenocarcinoma||Stomach||CT, Pathology||46||440|
|TCGA-THCA||Thyroid Cancer||Thyroid||CT, PT, Pathology||6||506|
|TCGA-UCEC||Uterine Corpus Endometrial Carcinoma||Uterus||CT, CR, MR, PT, Pathology||65||560|
Frederick National Lab Research Efforts
Imaging Source Site (ISS) Groups are being populated and were organized by the Cancer Imaging Informatics Lab within the Frederick National Laboratory for Cancer Research. The groups were governed by participants from institutions that have which provided imaging data to the archive for a given each TCGA cancer type. Modeled after the TCGA genomic analysis groups, ISS groups are given the opportunity were given a one year embargo window after 100 cases were accrued to publish a marker paper for a given cancer type per the guidelines in the table abovetype. This opportunity will generate increased participation in building these multi-institutional data sets as they become an open community resource. Current ISS groups includeincreased incentive among source sites to contribute their patients' images, which would ultimately become a public resource to enable radiogenomic research. The ISS groups included:
|TCGA Bladder Phenotype Research Group||Urothelial Bladder Carcinoma (BLCA)|
TCGA Collections Publication Guidelines
"The results <published or shown> here are in whole or part based upon data generated by the TCGA Research Network: http://cancergenome.nih.gov/."
The following links contain publications from the main TCGA project as well as their posted publication guidelines:
- TCIA Workshop at 2014 TCGA Symposium - Presented at TCGA Scientific Symposium, May 12, 2014 in Washington, DC.
- Imaging and Genomics: Is There a Synergy? - Published in Radiology 2012 ,264:329–31.
- A Scalable Methodology for Correlating Clinical Imaging Features with TCGA Data - Presented at TCGA Network Symposium, November 17–18, 2011 Washington, DC.
- The Cancer Imaging Archive: a Repository of Advanced Imaging Information Correlated with TCGA Samples - Presented at TCGA Network Symposium, November 17–18, 2011 Washington, DC.