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Summary

The TCGA Glioma Phenotype Research Group is part of the CIP TCGA Radiology Initiative focused on analyzing images from the TCGA-GBM and TCGA-LGG collections. The group began as an ad hoc multi-institutional research team dedicated to discovering the value of applying controlled terminology to the MR imaging features of patients with gliomas (see: VASARI Research Project).  Research trials that incorporate imaging present unique challenges due to nonstandard use of terminologies, absence of uniform data collection and validation. These obstacles traditionally limit the impact of imaging as an effective biomarker in oncology. The original purpose of this project was to assess reliability of tools and terminology developed by the Cancer Bioinformatics Grid (caBIG) initiative when performing a multireader simultaneous assessments of glioblastoma MR imaging features.  It has since grown into a number of diverse research initiatives conducted by geographically disparate open science research teams.

Starting or Joining a Research Project

We are currently hosting calls in support of TCGA glioma based research projects (TCGA-GBM or TCGA-LGG) on Tuesdays at 2pm Eastern. Please contact us at cancerimagingarchive@mail.nih.gov if you would like to inquire about setting up a new research project, discuss potential collaborations with existing groups or be otherwise kept in the loop as this effort moves forward.

Group Projects

This is a listing of ongoing projects.  If you are working with the TCGA glioma data hosted on TCIA please let us know and we would be happy to add a section describing your project here.

  • VASARI Research Project - Multiple readers reviewing TCGA brain cases and evaluating them based on the VASARI feature set and evaluating the results for reader agreement along with possible connection to related clinical/genetic/pathology data collected for the TCGA.  This project is being led by Adam Flanders at Thomas Jefferson University.
  • DSC T2* MR Perfusion Analysis - Survival prediction using molecular classification of glioblastomas using DSC T2* MR perfusion. This project has been accepted/presented at multiple conferences (see below) and is being led by Rajan Jain at Henry Ford Hospital.
  • Prediction of outcome using clinical, imaging and genetic information - This project seeks to use the VASARI Research Project output in combination with data from the TCGA Data Portal to evaluate survival and time to recurrence.  This project is being led by Max Wintermark and Manal Nicolas Jilwan of the University of Virginia.
  • Mapping of Edema/Cellular Invasion to MR Phenotypes - This project set out to present the first comprehensive radiogenomic analysis using quantitative MRI volumetrics and large-scale gene- and microRNA expression profiling in GBM.  This project was led by Pascal Zinn and Rivka Colen of MDACC and BWH respectively.
  • Growth Kinetics - A collaboration between Andrew Trister at Sage Bionetworks and Kristin Swanson at the University of Washington to make measurements of tumor growth kinetics in two modes (diffusion and proliferation) from pretreatment MRIs.
  • Man-machine correlation of VASARI features between human and machine observers - This project is being led by Dave Gutman (Emory) and Rivka Colen (BWH).
  • Analysis of Diffusion-Sensitized MRI for Predicting the Histopathologic, Genomic, and Clinical Features - This is a newer project being initiated and led by Scott Hwang at Emory University
  • CAD Texture Analysis - Led by Ashlee Byrd and Brad Erickson at Mayo, they are using multispectral features, including intensity, texture, and morphology, to identify imaging features that predict genetic patterns.

Publications

Citation

TCIA Shared Lists

Supporting Materials

Zinn PO, Sathyan P, Mahajan B, Bruyere J, Hegi M, et al. (2012)
A Novel Volume-Age-KPS (VAK) Glioblastoma Classification Identifies a Prognostic Cognate microRNA-Gene Signature.
PLoS ONE 7(8): e41522. doi:10.1371/journal.pone.0041522 (link)

 

 

Zinn PO, Majadan B, Sathyan P, Singh SK, Majumder S, et al. 2011
Radiogenomic Mapping of Edema/Cellular Invasion MRI-Phenotypes in Glioblastoma Multiforme.
PLoS ONE 6(10): e25451. doi:10.1371/journal.pone.0025451 (link)

Radiogenomic Mapping of Edema/Cellular Invasion MRI-Phenotypes

 

Note: For more information on how Shared Lists are used to cite and share data please view our TCIA Citation Guidelines.

Conference Abstracts

ASNR 2012 (April 21-26, 2012, New York, NY)

Presentations

Title

Time and Location

Supporting Materials

Imaging Genomic Mapping in Glioblastoma Multiforme: A Novel Quantitative Merge between Imaging and Genomics. The Creation of a Signature for Tumor Necrosis Using Image Genomic Analysis in 12, 764 genes and 555 microRNAs
Colen, R. R. * Mahajan, B. * Bruyere, J. * Jolesz, F. A. * Sathyan, P. * Zinn, P. O.

Mon, Apr 23, 3:08 - 3:16 PM: Grand Ballroom Suite, Session 15a - Adult Brain: Neoplasms I

Quantitative Histogram Analysis of Diffusion and Diffusion Tensor Imaging of Glioblastomas for the Prediction of Clinical Outcome: A TCGA Glioma Phenotype Research Group Project
Desai, H. * Hwang, S. N. * Holder, C. A. * Flanders, A. * Jilwan-Nicolas, M. * Kirby, J. * Saltz, J. * Gutman, D. A. * Raghavan, P. * Buetow, K. H. * TCGA Glioma Phenotype Research Group

Mon, Apr 23, 3:40 - 3:48 PM: Grand Ballroom Suite, Session 15a - Adult Brain: Neoplasms I

Survival Prediction in Glioblastoma: Role of Tumor Blood Volume versus Molecular Subclassification Using Genomic Mapping -- A TCGA Glioma Phenotype Research Group Project
Jain, R. * Poisson, L. * Narang, J. * Gutman, D. * Flanders, A. * Daniel, B. * Jaffe, C. * Mikkelsen, T. * TCGA Glioma Phenotype Research Group

Tue, Apr 24, 3:00 - 3:08 PM: Grand Ballroom Suite, Session 34a - Adult Brain Neoplasms III

Associations between Genomic Features and Quantitative Histogram Analysis of Diffusion and Diffusion Tensor Imaging of Glioblastomas: A TCGA Glioma Phenotype Research Group Project
Hwang, S. N. * Holder, C. A. * Desai, H. * Clifford, R. * Huang, E. * Hammoud, D. * Wintermark, M. * Colen, R. R. * Jain, R. * Freymann, J. * Flanders, A. * TCGA Glioma Phenotype Research Group

Tue, Apr 24, 3:32 - 3:40 PM: Grand Ballroom Suite, Session 34a - Adult Brain Neoplasms III.

Educational Exhibits

Title

Time and Location

Supporting Materials

Genomic Imaging: Creation of a Uniformed Terminology to Describe the Morphologic MR Imaging Features of Gliomas to Augment Clinical Research in the Genomics of Cancer: A TCGA Glioma Phenotype Research Group Project
Flanders, A. E. * Hwang, S. * Nicolas-Jilwan, M. * Raghavan, P. * Colen, R. R. * Gutman, D. * Jain, R. * Holder, C. A. * Wintermark, M. * Kirby, J. * Rubin, D. L. * TCGA Glioma Phenotype Research Group

Mon, Apr 23, 6:30 AM - 9:00 PM: Rhinelander, Session eEdE1 - Adult Brain (Electronic Education Exhibit)

Genomic Imaging: Gliomas and Perfusion Imaging: a TCGA Glioma Phenotype Research Group Project
Jain, R. * TCGA Glioma Phenotype Research Group

Mon, Apr 23, 6:30 AM - 9:00 PM: Rhinelander, Session eEdE1 - Adult Brain (Electronic Education Exhibit)

Imaging Genomics: Correlation of Invasive Genomic Composition and Patient Survival Using Qualitative and Quantitative MR Imaging Parameters
Colen, R. R. * Mahajan, B. * Flanders, A. * Huang, E. * Jain, R. * Gutman, D. * Hwang, S. * Kirby, J. * Freyman, J. * TCGA Glioma Phenotype Research Group * Jolesz, F. * Zinn, P. O.

Mon, Apr 23, 6:30 AM - 9:00 PM: Rhinelander, Session eEdE1 - Adult Brain (Electronic Education Exhibit)

Methodology for Imaging Genomics of Gliomas
Colen, R. R. * Mahajan, B. * Sathyan, P. * Kovacs, A. * Zinn, P. O. * Jolesz, F. A.

Mon, Apr 23, 6:30 AM - 9:00 PM: Rhinelander, Session eEdE1 - Adult Brain (Electronic Education Exhibit)

Posters

Title

Time and Location

Supporting Materials

Man vs Machine - Validation of the Qualitative Imaging Feature Set VASARI Using Volumetric Analysis by 3 D Slicer of the TCGA GBM Dataset: A TCGA Glioma Phenotype Research Group Project
Gutman, D. A. * Huang, E. * Flanders, A. * Mikkelsen, T. * Scarpace, L. * Holder, C. * Hwang, S. * Aurora, T. * Jolesz, F. A. * Saltz, J. * Colen, R. * TCGA Glioma Phenotype Research Group

Monday, Apr 23, 2012, 6:30 AM - 3:00 PM: Americas Hall II, Session P1 - Adult Brain (Printed Poster)

Imaging Genomic Mapping of Edema/Cellular Invasion MR Imaging-Phenotypes in Glioblastoma Multiforme
Zinn, P. O. * Mahajan, B. * Sathyan, P. * Singh, S.* Majumder, S. * Flanders, A.* Huang, E. * Jain, R.* Gutman, D. * Hwang, S.* Kirby, J. * Freyman, J. * Holder, C. * Wintermark, M. * TCGA Glioma Phenotype Research Group * Jolesz, F. A. * Colen, R. R.

Monday, Apr 23, 2012, 6:30 AM - 3:00 PM: Americas Hall II, Session eP1 - Adult Brain (Electronic Poster)

Introduction into Imaging Genomic Mapping in Brain Tumors
Colen, R. R. * Mahajan, B. * Jolesz, F. A. * Zinn, P. O.

Monday, Apr 23, 2012, 6:30 AM - 3:00 PM: Americas Hall II, Session eP1 - Adult Brain (Electronic Poster)

Radiogenogram: MR Imaging as a Screening Tool for Uncovering Novel Genomic Drug Targets
Colen, R. R. * Sathyan, P. * Jolesz, F. A. * Zinn, P. O.

Monday, Apr 23, 2012, 6:30 AM - 3:00 PM: Americas Hall II, Session eP1 - Adult Brain (Electronic Poster)

RSNA 2011 (Nov 27-Dec 2, 2011, Chicago, IL)

Title

Presentation Time (CST) and Location

Supporting Materials

A Coordinated Method for Clinical Trials Research: Multireader Assessment of MR Imaging Features of Human Gliomas
A E Flanders, MD, Philadelphia, PA; E Huang, PhD; M Wintermark, MD; M Nicolas-Jilwan, MD; P Raghavan, MD; C A Holder, MD; et al.

Tue Nov 29 2011 9:25AM - 9:35AM ROOM E451B

Computer-aided Visual Image Analysis of Glioblastomas and Genomic Features
S N Hwang, PhD,MD, Atlanta, GA; C A Holder, MD; E Huang, PhD; R A Clifford; D Hammoud, MD; P Raghavan, MD; et al.

Sun Nov 27 2011 12:30PM - 1:00PM ROOM Lakeside Learning Center (poster)

Mon Nov 28 2011 11:10AM - 11:20AM ROOM N226 (oral)

A Novel Statistical Method for Lossless Compression of Diagnostic Imaging Features
E Huang, PhD, Rockville, MD; J B Freymann, BS; J Kirby; R A Clifford; C Jaffe, MD; A E Flanders, MD

Wed Nov 30 2011 12:15PM - 12:45PM ROOM Lakeside Learning Center

Prediction of Glioblastoma Multiforme (GBM) Time to Recurrence Using MRI Image Features and Gene Expression
M Nicolasjilwan, MD, Charlottesville, VA; R A Clifford; A E Flanders, MD; L Scarpace; P Raghavan, MD; D Hammoud, MD; et al.

Thu Dec 01 2011 11:50AM - 12:00PM ROOM N229

Radiogenomic Mapping in GBM: A Novel Quantitative Merge between Imaging and Genomics - The Creation of a Signature for Tumor Necrosis Using Image Genomic Analysis in 12, 764 genes and 555 microRNAs
R R Colen, MD, Boston, MA; P O Zinn, MD; J R Bruyere, BS,MA; B Mahajan, MBBS; F A Jolesz, MD

Tue Nov 29 2011 11:00 AM - 11:10 AM ROOM E451B

SNO 2011 (Nov 17-20, 2011, Orange County, CA)

Title

Supporting Materials

Radiogenomic Mapping in GBM in Patients with High versus Low Edema/Tumor Infiltration using An Image- Genomic Analysis of 12, 764 genes and 555 microRNAs
Rivka R. Colen, Bhanu Mahajan, Ferenc A. Jolesz, Pascal O. Zinn

Survival prediction using molecular classification of glioblastomas: Role of tumor blood volume estimation using DSC T2* MR perfusion
Rajan Jain, Laila Poisson, Jayant Narang, Lisa Scarpace, David Gutman, Carl Jaffe, Joel Saltz, Adam Flanders, Brat Daniel, Tom Mikkelsen

The Cancer Genome Atlas Network Symposium (Nov 17-18, 2011, Washington, DC)

Title

Supporting Materials

Neuroimaging Predictors of Survival, Pathology, and Molecular Profiles in TCGA Glioblastomas
David A Gutman, Lee A.D. Cooper, Joel Saltz, Adam Flanders, Dan Brat and the TCGA Glioma Phenotype Research Group

ASNR 2011 (June 4-9, 2011, Seattle, WA)

Title

Supporting Materials

Relationship between MR Imaging Features, Gene Expression Subtype, and Histopathologic Features of Glioblastomas
Hwang SN, Clifford R, Huang E, Hammoud D, Jilwan M, Raghavan P, Wintermark M, Gutman DA, Moreno C, Cooper L, Freymann J, Kirby J, Krishnan A, Dehkharghani S, Jaffe C, Saltz JH, Flanders A, Brat DJ, Holder CA

Associations Between MR Imaging and Genomic Features of Glioblastomas
Hwang SN, Holder CA Huang E, Clifford R, Hammoud D, Raghavan P, Jilwan M, Wintermark M, Gutman DA, Cooper L, Moreno C, Kirby J, Freymann J, Dehkharghani S, Krishnan A, Jaffe C, Flanders A, Saltz JH, Brat DJ

A Methodology for Multi-reader Assessment of MR Imaging Features of Gliomas in Clinical Trials
Flanders, A. Huang E, Wintermark M, Hammoud D, Jilwan, M. Raghaven, Holder C, Hwang S, Clifford R, Freymann J, Kirby J, Jaffe C C

Prediction of Glioblastoma Multiforme (GBM) Patient Survival Using MRI Image Features and Gene Expression
Nicolasjilwan M, Clifford R, Raghavan P, Wintermark M, Hammoud D, Huang E, Jaffe C, Freymann J, Kirby J, Buetow K, Huang S, Holder C

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